Liver Int:大麻的使用与酗酒患者肝脏疾病的发病率减少有关

2018-01-22 MedSci MedSci原创

大麻的使用与酗酒患者肝脏疾病的发病率减少有关。

滥用酒精对健康有很大的影响,包括引起肝病(如:酒精性脂肪变性(AS)、脂肪肝(AH)、纤维化、肝硬化(AC)和肝细胞癌(HCC))。令人惊讶的是,大量滥用酒精的人也使用大麻,在全球范围内已经增加了大麻合法化。虽然大麻具有抗炎的特性,在滥用酒精的同时使用大麻对肝脏疾病的影响仍不清楚。本研究的目的是检测大麻对滥用酒精的肝病患者发病率的影响。

本研究分析了2014年18岁及大于18岁患者的全国住院患者样本(NIS)的出院记录。研究共纳入319514例有嗜酒病史和目前仍然嗜酒的患者。使用国际疾病分类,根据大麻暴露状态[非大麻使用患者(90.39%),不依赖大麻患者(8.26%),依赖大麻患者(1.36%)],研究将酒精性肝病疾病进展分为4个阶段。研究采用了复杂的调查抽样方法,计算相对于大麻暴露量,酒精性脂肪变性(AS)、脂肪肝(AH)、肝硬化(AC)和肝细胞癌(HCC)的调整比值比。

研究结果表明,在酒精使用患者中,另外使用大麻(依赖和非依赖大麻)的患者个体发展为AH, AC和HCC ((AOR: 0.55[0.48-0.64], 0.57[0.53-0.61],0.45[0.43-0.48]和0.62[0.51-0.76])的比率显著降低。进一步的研究表明,与非依赖大麻患者相比,依赖大麻的患者患肝脏疾病的几率要低得多。

大麻的使用与酗酒患者肝脏疾病的发病率减少有关。

原始出处

Adejumo AC, Ajayi TO, Adegbala OM, et al. Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease.Liver Int, 2018, Jan 17. doi: 10.1111/liv.13696.

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    2018-02-05 orangesking

    看看

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    2018-01-26 1e0e5a1fm42(暂无匿称)

    henhao

    0

  4. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Tue Jan 23 21:31:59 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281311, encodeId=f84a281311cd, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 23 19:33:24 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281297, encodeId=4d0028129efd, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Tue Jan 23 19:29:20 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-25 1e0e5697m83(暂无匿称)

    henhao

    0

  5. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Tue Jan 23 21:31:59 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281311, encodeId=f84a281311cd, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 23 19:33:24 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281297, encodeId=4d0028129efd, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Tue Jan 23 19:29:20 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-25 139****0239

    henhao

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Tue Jan 23 21:31:59 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281311, encodeId=f84a281311cd, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 23 19:33:24 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281297, encodeId=4d0028129efd, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Tue Jan 23 19:29:20 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Tue Jan 23 21:31:59 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281311, encodeId=f84a281311cd, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 23 19:33:24 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281297, encodeId=4d0028129efd, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Tue Jan 23 19:29:20 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-24 kcb069
  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Tue Jan 23 21:31:59 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281311, encodeId=f84a281311cd, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 23 19:33:24 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281297, encodeId=4d0028129efd, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Tue Jan 23 19:29:20 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 hhh678

    henhao

    0

  9. 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encryptionId=12c98145216, topicName=肝脏疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Wed Jan 24 09:34:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272714, encodeId=2c6e12e271458, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jan 24 09:34:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281338, encodeId=a4d128133871, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Tue Jan 23 21:31:59 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281311, encodeId=f84a281311cd, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 23 19:33:24 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281297, encodeId=4d0028129efd, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Tue Jan 23 19:29:20 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 虈亣靌

    谢谢.学习受益匪浅

    0

  10. 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createdName=1e0e5697m83(暂无匿称), createdTime=Thu Jan 25 20:24:24 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281950, encodeId=2dc028195010, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Thu Jan 25 19:55:19 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253383, encodeId=88e1125338373, content=<a href='/topic/show?id=12c98145216' target=_blank style='color:#2F92EE;'>#肝脏疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81452, 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level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Tue Jan 23 19:29:20 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 139****0239

    henhao

    0

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NEJM:非酒精性脂肪性肝炎的成因及管理

近日,权威医学刊物《新英格兰医学》发表了一篇指导性文献《非酒精性脂肪性肝炎的成因、发病机制及治疗》。

JAMA Psychiatry:伐仑克林可实现重度酒精以及烟草依赖戒断

研究认为,伐仑克林可降低男性人群严重酗酒率,同时降低所有人群的吸烟率

BEHAV BRAIN RES:布洛芬可以阻断胎儿酒精暴露造成的损害

行为和认知障碍在诊断为胎儿酒精谱系障碍(FASD)的个体中很常见。胎儿酒精谱系障碍包括异常执行功能,学习和记忆的缺陷等。

Nature:小酌怡情大错特错!酒精代谢物诱使干细胞突变!

在前面推送的WHO的致癌物中,我们发现酒及其制品会诱发癌症。但是大多数人依旧坚信着“小酌怡情”,相信少量饮酒是有益处的。而在今日,《Nature》发文坐实:酒精和内源醛类物质损害染色体及使干细胞发生突变!

PLoS One:循环性激素与人体测量学、社会统计学和行为因素相关

性激素是许多疾病的病因。为了更好的理解疾病病因和疾病风险因素机制之间的相关性,最近,有研究人员进行了旨在调查人体测量学、社会统计学和行为因素与一些循环性激素和性激素结合球蛋白之间的相关性。研究包括了12330名年龄在25-85岁的来自25个研究的男性参与者。研究发现,更大的年龄与更高浓度的性激素结合球蛋白和二氢睾酮、以及更低浓度的硫酸脱氢表雄酮、游离睾酮、雄烯二酮和、雄甾烷二醇葡萄糖苷酸和游离雌二