JCEM:HbA1c“火眼金睛”识别糖尿病前期和亚临床心脏改变患者

2017-08-02 MedSci MedSci原创

大家都知道糖尿病前期与发展至心力衰竭的亚临床心脏改变有关,2017年8月1日在JCEM上发表的一篇文章研究了在糖尿病前期患者中舒张功能与糖基化及心血管相关疾病炎症标志物的关系。

大家都知道糖尿病前期与发展至心力衰竭的亚临床心脏改变有关,2017年8月1日在JCEM上发表的一篇文章研究了在糖尿病前期患者中舒张功能与糖基化及心血管相关疾病炎症标志物的关系。

该研究聚焦于糖尿病前期的患者,只通过糖化血红蛋白A1c确诊[HbA1c 5.7-6.4%,口服葡萄糖耐量试验(OGTT)后空腹血糖正常(NFG)、糖耐量正常(NGT)]。共纳入167例NFG/NGT受试者,根据HbA1c水平分为两组:对照组(HbA1c<5.7%和NFG / NGT);糖化血红蛋白糖尿病前期组(HbA1c 5.7-6.4%和NFG / NGT)。所有受试者评估糖化血红蛋白、OGTT、空腹超声心动图、可溶性糖基化终末产物受体(sRAGE)、内源性分泌型RAGE(esRAGE)和S100A12。

HbA1c糖尿病前期患者(n=106)较对照组(n=61)显示出较低的E/A比值(1.10±0.24 vs 1.18±0.23,P<0.05);除此之外,他们表现出较高的左心房容积(LAV)(28.4±5 vs 22.1±3,P<0.05)和球形指数(SI)(0.6±0.06 vs 0.5±0.05,P<0.05)。多元回归分析后,HbA1c、和esRAGE与E/A比值有关;LAV的主要决定因素是HbA1c和sRAGE,而SI与HbA1c有关。

该研究表明HbA1c糖尿病前期患者表现出亚临床心脏改变:降低的E/A比值、较高的LAV和受损的SI; sRAGE、esRAGE和HbA1c水平与这些变化相关。而这些人以空腹血糖或OGTT检查结果是不会被列为糖尿病前期的。

原始出处:


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    2018-01-16 Smile2680
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    2017-09-11 achengzhao
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    2017-12-16 smallant2015
  5. [GetPortalCommentsPageByObjectIdResponse(id=2015915, encodeId=a367201591545, content=<a href='/topic/show?id=33108494c1' target=_blank style='color:#2F92EE;'>#HbA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8494, encryptionId=33108494c1, topicName=HbA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Tue Jan 16 01:20:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070335, encodeId=466320e0335fc, content=<a href='/topic/show?id=4b0d66896b9' target=_blank style='color:#2F92EE;'>#火眼金睛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66896, encryptionId=4b0d66896b9, topicName=火眼金睛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Fri Apr 06 13:20:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063018, encodeId=4871206301867, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Sep 11 08:20:00 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777636, encodeId=ec3f1e7763678, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sat Dec 16 19:20:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229908, encodeId=5e5322990816, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Fri Aug 04 10:04:49 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229393, encodeId=4a3c22939327, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Thu Aug 03 05:50:39 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229336, encodeId=eeb722933647, content=糖化血红蛋白可以作为糖尿病前期的诊断指标5.7-6.4%, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIGva1VbaRlG8lACKpAIg0q7yx3DfEg0JkozvKSiabsnnZDpPTVDYvLboGpdeWt1tB3mt1xaO70p9A/132, createdBy=749e1954591, createdName=Fanny-fanfan, createdTime=Wed Aug 02 23:27:46 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2017-08-04 往日如昨

    继续学习中谢谢

    0

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    2017-08-03 184****9840

    学习了谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2015915, encodeId=a367201591545, content=<a href='/topic/show?id=33108494c1' target=_blank style='color:#2F92EE;'>#HbA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8494, encryptionId=33108494c1, topicName=HbA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Tue Jan 16 01:20:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070335, encodeId=466320e0335fc, content=<a href='/topic/show?id=4b0d66896b9' target=_blank style='color:#2F92EE;'>#火眼金睛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66896, encryptionId=4b0d66896b9, topicName=火眼金睛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Fri Apr 06 13:20:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063018, encodeId=4871206301867, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Sep 11 08:20:00 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777636, encodeId=ec3f1e7763678, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sat Dec 16 19:20:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229908, encodeId=5e5322990816, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Fri Aug 04 10:04:49 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229393, encodeId=4a3c22939327, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Thu Aug 03 05:50:39 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229336, encodeId=eeb722933647, content=糖化血红蛋白可以作为糖尿病前期的诊断指标5.7-6.4%, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIGva1VbaRlG8lACKpAIg0q7yx3DfEg0JkozvKSiabsnnZDpPTVDYvLboGpdeWt1tB3mt1xaO70p9A/132, createdBy=749e1954591, createdName=Fanny-fanfan, createdTime=Wed Aug 02 23:27:46 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2017-08-02 Fanny-fanfan

    糖化血红蛋白可以作为糖尿病前期的诊断指标5.7-6.4%

    0

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