Clinica Chimica Acta：血清GP73联合AST和GGT可反映慢性乙型肝炎中、重度肝炎症？

2019-08-08 不详 MedSci原创

目前，对于至少中度炎性病变但没有增加<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-family:宋体;mso-bidi-font-family:"Ti

目前，对于至少中度炎性病变但没有增加ALT的慢性乙型肝炎（CHB）患者的诊断，尚无非侵入性方法。

在此，研究人员评估了基于高尔基体蛋白73（GP73）的肝脏炎症模型（HIM）作为肝脏坏死性炎症活动的血清替代物，特别是那些ALT低于传统上限浓度的患者。采用ROC曲线分析方法，对2组经肝活检证实为慢性乙型肝炎的独立队列患者进行诊断。

HIM作为综合GP73，γ-谷氨酰转移酶和AST的指标，可以显著提高肝脏坏死性炎症的诊断准确性（ROC下面积，AUROC：0.890）。更重要的是，对于至少具有中度肝脏坏死性炎症活性但ALT <40U / l的患者，HIM仍然表现出极好的诊断价值（AUROC：0.873）。诊断模型准确性的主要改善来源为血清GP73。

研究表明，HIM是一个非常有前景的识别中度到重度的慢性乙肝患者肝脏坏死性炎症非侵入性指标，特别是对于那些ALT < 40 U / l的患者。

原始出处：

MingjieYao，Leijie Wang，Serum GP73 combined AST and GGT reflects moderate to severe liver inflammation in chronic hepatitis B

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2021-03-23 病毒猎手

#GP73#

0 0
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2020-10-02 ms1000001995549278

再看看

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2020-01-09 okhuali

#乙型肝炎#

31 0
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2019-10-20 windight

#CTA#

28 0
[GetPortalCommentsPageByObjectIdResponse(id=950514, encodeId=532395051448, content=<a href='/topic/show?id=4a0281923d' target=_blank style='color:#2F92EE;'>#GP73#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8192, encryptionId=4a0281923d, topicName=GP73)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Mar 23 23:02:38 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889659, encodeId=64e6889659d6, content=再看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=03ad5423123, createdName=ms1000001995549278, createdTime=Fri Oct 02 08:34:10 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825703, encodeId=70091825e0314, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Thu Jan 09 16:19:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849675, encodeId=f27718496e55f, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Oct 20 10:19:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712059, encodeId=28641e1205952, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Oct 31 14:19:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763355, encodeId=41dd1e63355d0, content=<a href='/topic/show?id=b190e99445' target=_blank style='color:#2F92EE;'>#GGT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7994, encryptionId=b190e99445, topicName=GGT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa3237493049, createdName=ms4964546379600229, createdTime=Tue Mar 10 15:19:00 CST 2020, time=2020-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271293, encodeId=e06312e129356, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Sat Aug 10 06:19:00 CST 2019, time=2019-08-10, status=1, ipAttribution=)]
2019-10-31 ms24272190615788285182

#AST#

27 0
[GetPortalCommentsPageByObjectIdResponse(id=950514, encodeId=532395051448, content=<a href='/topic/show?id=4a0281923d' target=_blank style='color:#2F92EE;'>#GP73#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8192, encryptionId=4a0281923d, topicName=GP73)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Mar 23 23:02:38 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889659, encodeId=64e6889659d6, content=再看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=03ad5423123, createdName=ms1000001995549278, createdTime=Fri Oct 02 08:34:10 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825703, encodeId=70091825e0314, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Thu Jan 09 16:19:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849675, encodeId=f27718496e55f, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Oct 20 10:19:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712059, encodeId=28641e1205952, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Oct 31 14:19:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763355, encodeId=41dd1e63355d0, content=<a href='/topic/show?id=b190e99445' target=_blank style='color:#2F92EE;'>#GGT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7994, encryptionId=b190e99445, topicName=GGT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa3237493049, createdName=ms4964546379600229, createdTime=Tue Mar 10 15:19:00 CST 2020, time=2020-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271293, encodeId=e06312e129356, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Sat Aug 10 06:19:00 CST 2019, time=2019-08-10, status=1, ipAttribution=)]
2020-03-10 ms4964546379600229

#GGT#

34 0
[GetPortalCommentsPageByObjectIdResponse(id=950514, encodeId=532395051448, content=<a href='/topic/show?id=4a0281923d' target=_blank style='color:#2F92EE;'>#GP73#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8192, encryptionId=4a0281923d, topicName=GP73)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Mar 23 23:02:38 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889659, encodeId=64e6889659d6, content=再看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=03ad5423123, createdName=ms1000001995549278, createdTime=Fri Oct 02 08:34:10 CST 2020, time=2020-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825703, encodeId=70091825e0314, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Thu Jan 09 16:19:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849675, encodeId=f27718496e55f, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Oct 20 10:19:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712059, encodeId=28641e1205952, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Oct 31 14:19:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763355, encodeId=41dd1e63355d0, content=<a href='/topic/show?id=b190e99445' target=_blank style='color:#2F92EE;'>#GGT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7994, encryptionId=b190e99445, topicName=GGT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa3237493049, createdName=ms4964546379600229, createdTime=Tue Mar 10 15:19:00 CST 2020, time=2020-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271293, encodeId=e06312e129356, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Sat Aug 10 06:19:00 CST 2019, time=2019-08-10, status=1, ipAttribution=)]
2019-08-10 guguangxiang

#慢性乙型肝炎#

32 0

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Clinica Chimica Acta：血清GP73联合AST和GGT可反映慢性乙型肝炎中、重度肝炎症？

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