阜外研究:≥80岁心梗患者脑卒中发生率高

2018-04-07 岱西 中国循环杂志

高危、高龄,一直是让人关注的患者群体。那些行直接经皮冠脉介入治疗(PPCI),并需主动脉内球囊反搏(IABP)辅助支持的≥80岁的急性心肌梗死患者临床转归如何?


高危、高龄,一直是让人关注的患者群体。那些行直接经皮冠脉介入治疗(PPCI),并需主动脉内球囊反搏(IABP)辅助支持的≥80岁的急性心肌梗死患者临床转归如何?
 
阜外医院张沛等通过对比≥80岁和<80岁这类患者进行研究显示,≥80岁患者术后2 年死亡率显著增高;术后1个月主要不良心脑血管事件(MACCE)显著增高,主要为卒中事件显著增加。年龄≥80岁对各终点事件均无显著的预测效应。
 
研究显示,≥80岁组术后1个月MACCE发生率为41.2%,显著高于<80岁组的24.5%,其中卒中发生率明显增加(9.8% vs 0.8%)。
 
不过,两组术后1 个月(17.6% vs 15.2%)和1 年死亡率(25.5%vs 16.9%)死亡率无统计学差异。但≥80岁组至术后2 年时死亡率显著增高(35.3% vs 20.7%)。
 
进一步分析显示,术后TIMI血流<3级对于患者短期和长期生存均是最强独立预测因子。这提示,有效再灌注对STEMI中高危缺血人群意义深重。
 
研究还显示,心功能Killip 分级≥ 2级、左心室射血分数(LVEF)≤40%及术前收缩压≤100 mmHg等因素对患者的预后也有显著甚至较强的预测效力。此外,既往脑血管病史对PPCI术后1年和2年死亡也有一定预测效应。
 
研究还提示,对于≥80岁这部分高危人群,高龄可能已非影响其预后的决定因素。即研究结果支持介入治疗降低各年龄段冠心病患者死亡率,且年龄≥80岁高龄患者净获益最大的研究结论。
 
该研究共纳入288例因急性心梗而行PPCI,并需IABP支持的患者,其中≥80岁者51例,<80岁者237例。
 
原始出处:

张沛,戴军,张朝阳,等. 年龄≥ 80岁和年龄<80岁的急性ST段抬高型心肌梗死患者主动脉内球囊反搏支持下直接经皮冠状动脉介入治疗预后的对比研究. 中国循环杂志, 2018, 33: 217-221.

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    2018-04-09 1881fcc0c6m

    感觉是显而易见的结论啊

    0

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    2018-04-08 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1826435, encodeId=e83f1826435ee, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Dec 13 14:18:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049476, encodeId=886d20494e699, content=<a href='/topic/show?id=5c2e5106290' target=_blank style='color:#2F92EE;'>#心梗患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51062, encryptionId=5c2e5106290, topicName=心梗患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Thu Jun 28 23:18:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304028, encodeId=6bbf3040289b, content=感觉是显而易见的结论啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be7c2131129, createdName=1881fcc0c6m, createdTime=Mon Apr 09 02:11:42 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026006, encodeId=60191026006e9, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Apr 08 01:18:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303682, encodeId=7e4d303682dc, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Apr 07 23:08:47 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303677, encodeId=82bb3036e730, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Sat Apr 07 22:54:45 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303672, encodeId=76c33036e2b4, content=心脑血管疾病与年龄呈正相关., beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Apr 07 22:44:23 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303664, encodeId=52e73036648b, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat Apr 07 22:27:50 CST 2018, time=2018-04-07, status=1, ipAttribution=)]
    2018-04-07 131****2916

    不错的文章值得推荐

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1826435, encodeId=e83f1826435ee, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Dec 13 14:18:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049476, encodeId=886d20494e699, content=<a href='/topic/show?id=5c2e5106290' target=_blank style='color:#2F92EE;'>#心梗患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51062, encryptionId=5c2e5106290, topicName=心梗患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Thu Jun 28 23:18:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304028, encodeId=6bbf3040289b, content=感觉是显而易见的结论啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be7c2131129, createdName=1881fcc0c6m, createdTime=Mon Apr 09 02:11:42 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026006, encodeId=60191026006e9, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Apr 08 01:18:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303682, encodeId=7e4d303682dc, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Apr 07 23:08:47 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303677, encodeId=82bb3036e730, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Sat Apr 07 22:54:45 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303672, encodeId=76c33036e2b4, content=心脑血管疾病与年龄呈正相关., beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Apr 07 22:44:23 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303664, encodeId=52e73036648b, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat Apr 07 22:27:50 CST 2018, time=2018-04-07, status=1, ipAttribution=)]
    2018-04-07 wqkm

    ^_^^_^^_^

    0

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    2018-04-07 1e0f8808m18(暂无匿称)

    心脑血管疾病与年龄呈正相关.

    0

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    2018-04-07 天地飞扬

    学习了.谢谢分享!

    0

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