AM J HYPERTENS:孕期母亲叶酸水平高,孩子得高血压风险降低40%

2017-03-15 卢芳 中国循环杂志

怀孕前后补点什么好?好多人会回答叶酸,因为这样有助于预防胎儿神经管发育缺陷。不过近期中美学者进行的研究又给补充叶酸增添了新理由:母亲叶酸水平高,能够降低孩子40%的儿童期血压升高风险。而且在这项研究中很多母亲有高血压、糖尿病以及体重超标这些心脏代谢风险因素。而之前有研究表明,孕期母亲心脏代谢危险因素与后代血压升高相关。这项研究也验证了这一点:随访中那些血压高的儿童,其母亲也多肥胖、有高血压或糖尿病

怀孕前后补点什么好?好多人会回答叶酸,因为这样有助于预防胎儿神经管发育缺陷。不过近期中美学者进行的研究又给补充叶酸增添了新理由:母亲叶酸水平高,能够降低孩子40%的儿童期血压升高风险。

而且在这项研究中很多母亲有高血压糖尿病以及体重超标这些心脏代谢风险因素。而之前有研究表明,孕期母亲心脏代谢危险因素与后代血压升高相关。

这项研究也验证了这一点:随访中那些血压高的儿童,其母亲也多肥胖、有高血压糖尿病

此外,从一个人生命历程来看,小时候血压高,长大后血压也多异常升高,进而高血压相关的各种心脑血管疾病等也就跟着来了。

研究者指出,该研究进一步为高血压的早期生命起源提供了新证据,提示在怀孕前和怀孕时进行风险评估和干预,或能有效预防子代高血压的发生。

这项来自美国波士顿医疗中心的研究,共分析了1290对母子,其中67.8%为黑人,19.2%为西班牙人,并对儿童生长状况追踪随访到9岁。其中28.7%的儿童在3~9岁时收缩压升高。

在这些母亲中有38.2%的人有一种或多种心脏代谢危险因素;其中14.6%有高血压,11.1%有糖尿病,25.1%孕前肥胖。

不过有关叶酸的研究,还有一些争议:JAMA:叶酸补充预防神经管缺陷

原始出处:

Hongjian Wang, Noel T. Mueller, Jianping Li, et al. Association of Maternal Plasma Folate and Cardiometabolic Risk Factors in Pregnancy with Elevated Blood Pressure of Offspring in Childhood. American Journal of Hypertension. March 6.2017

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    2017-11-07 feather89
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    2017-06-18 laoli

    学习了,谢谢分享!

    0

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  5. 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channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2291960840, createdName=蓬莱阁, createdTime=Thu Mar 16 07:35:37 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180203, encodeId=284118020301, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Mar 16 05:20:07 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180168, encodeId=1fd218016876, content=很好的学习资料,谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Wed Mar 15 23:35:51 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-04-07 脱因不花

    所以在孕期要补充好叶酸

    0

  6. 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channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2291960840, createdName=蓬莱阁, createdTime=Thu Mar 16 07:35:37 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180203, encodeId=284118020301, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Mar 16 05:20:07 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180168, encodeId=1fd218016876, content=很好的学习资料,谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Wed Mar 15 23:35:51 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-03-16 明天会更好!

    文章不错,值得分享!

    0

  7. 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channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2291960840, createdName=蓬莱阁, createdTime=Thu Mar 16 07:35:37 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180203, encodeId=284118020301, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Mar 16 05:20:07 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180168, encodeId=1fd218016876, content=很好的学习资料,谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Wed Mar 15 23:35:51 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-03-16 1e10c84am36(暂无匿称)

    文章不错,值得分享

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:52:04 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180297, encodeId=fff018029e6c, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:01:07 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180237, encodeId=9f1a18023e4e, content=学习了。赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2291960840, createdName=蓬莱阁, createdTime=Thu Mar 16 07:35:37 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180203, encodeId=284118020301, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Mar 16 05:20:07 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180168, encodeId=1fd218016876, content=很好的学习资料,谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Wed Mar 15 23:35:51 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-03-16 蓬莱阁

    学习了。赞一个

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:52:04 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180297, encodeId=fff018029e6c, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:01:07 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180237, encodeId=9f1a18023e4e, content=学习了。赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2291960840, createdName=蓬莱阁, createdTime=Thu Mar 16 07:35:37 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180203, encodeId=284118020301, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Mar 16 05:20:07 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180168, encodeId=1fd218016876, content=很好的学习资料,谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Wed Mar 15 23:35:51 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-03-16 刘煜

    学习了谢谢分享

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Mar 16 10:52:04 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180297, encodeId=fff018029e6c, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Mar 16 10:01:07 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180237, encodeId=9f1a18023e4e, content=学习了。赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2291960840, createdName=蓬莱阁, createdTime=Thu Mar 16 07:35:37 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180203, encodeId=284118020301, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Mar 16 05:20:07 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180168, encodeId=1fd218016876, content=很好的学习资料,谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Wed Mar 15 23:35:51 CST 2017, time=2017-03-15, status=1, ipAttribution=)]
    2017-03-15 1e15b6fem30(暂无匿称)

    很好的学习资料,谢谢了。

    0

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高血糖是卒中的重要危险因素。近期南方医科大学侯凡凡等在高血压人群中进行的研究显示,空腹血糖≥7 mmol/L或糖尿病均可增加首次卒中风险,而补充叶酸可降低34%的这种风险。 研究显示,空腹血糖<5 mmol/L者首次卒中发生率为2.6%,而空腹血糖≥7 mmol/L或糖尿病者则高达6%。 而每日补充0.8 mg叶酸,对于空腹血糖≥5 mmol/L者都有预防卒中作用,但在空腹血糖

JAMA:叶酸补充预防神经管缺陷

2017年1月,美国预防服务工作组发表在《JAMA》的更新的证据报道和系统回顾,考察了叶酸补充对神经管缺陷的预防作用。

Lancet: 中国学者证实叶酸带来的“好孕”

围孕期叶酸的使用已经得到了广泛的推荐,以减少新生儿神经管缺陷的风险。但是,对其他出生缺陷和不良妊娠结局的影响,以及叶酸使用的时间窗需要进一步调查研究。近期,一项发表在Lancet上的文章综合评估了育龄妇女的围孕期使用叶酸对妊娠结局的影响。中国国家免费孕前健康检查项目(HFPHEP)于2010成立,是国家针对31个省所有夫妇的项目,评估计划怀孕夫妇在孕前4-6个月的出生缺陷风险因素。研究者们收集了2

JAMA Intern Med:侯凡凡院士发现叶酸可延缓慢性肾脏病进展

南方医科大学侯凡凡院士与徐欣教授研究证实,适量补充叶酸可明显延缓高血压患者肾脏病变的发展,降低慢性肾脏病发展为尿毒症的风险。

Am J Kidney Dis:孕妇叶酸及维生素B12可以影响儿童的肾脏

在怀孕期间叶酸、维生素B12和同型半胱氨酸浓度是胎儿早期发育的重要因素,并且可能持续影响幼儿的肾功能。近期,一项发表在Am J Kidney Dis杂志上的文章评估了在怀孕期间叶酸、维生素B12和同型半胱氨酸浓度与学校儿童的肾脏之间的关联。此项研究是从胎儿生命开始的基于人群的前瞻性队列研究。研究在4226名孕妇及其子女中进行。在早孕(中位孕龄,13.2 [IQR,12.2-14.8]周)和出生时(