J Clin Pharm Ther:克林霉素不良反应新报道

2017-04-22 sunshine2015 来宝网

4月17日在“临床药学和治疗学杂志”上发表的病例报告中,描述了服用克林霉素治疗感染性疾病继发的急性全身性除鳞性脓疱疮的病例。

4月17日在“临床药学和治疗学杂志”上发表的病例报告中,描述了服用克林霉素治疗感染性疾病继发的急性全身性除鳞性脓疱疮的病例。

来自查尔斯顿南卡罗来纳医学中心医科大学的Colleen Croy医生以及他的同事介绍了一名二十二岁男子患有舌肿胀和吞咽困难的病例。早在八天前,他就注意到了自己的右手的第五位手指上出现了一个疙瘩,并除掉了那个疙瘩。疙瘩被除去后手就已经被感染了。这位患者后来被确诊为蜂窝组织炎而入院,并开始静脉注射克林霉素进行治疗。三天以后,又将万古霉素加入治疗方案中。五天后静脉注射克林霉素,其中有两天也同时用静脉注射万古霉素,患者出院后以未知剂量继续口服克林霉素。

病人第二天出现了发烧和皮疹恶化的现象。接下来皮疹便蔓延到了舌头的粘膜处。入院治疗急性皮肤发疹和持续性蜂窝组织炎后,根据皮疹表现、时间过程、缺乏嗜酸性粒细胞、肝酶升高和皮肤活检等情况,将患者的皮疹分类确定为应用克林霉素治疗继发的急性全身性化脓性脓疱病。用口服苯海拉明和口服法莫替丁对患者进行症状治疗。开始静脉注射利奈唑胺治疗活动性蜂窝组织炎。

作者写道:“这一案例强调了应对不良药物反应,确定反应和确定致病因子的重要性。”

原始出处:

C. Croy, et al.  Clindamycin-associated acute generalized exanthematous pustulosis.  Journal of Clinical Pharmacy and Therapeutics.First published: 17 April 2017

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    2018-02-09 jj000001
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Sun Apr 23 21:06:46 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189947, encodeId=ac9b18994ee0, content=更多的不良反应发生在小诊所小医院,没报告,没报道,, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/16/3ae1e86599052c0bb20c612346853774.jpg, createdBy=1f402044809, createdName=1881ea7c1dm, createdTime=Sun Apr 23 16:21:22 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189941, encodeId=848f1899413f, content=不良反应经常碰到,林可霉素严重过敏休克2例,幸好及时抢救,一切还好,大汗啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:01:02 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-05-03 绛珠草小姐

    学习了,谢谢分享

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:01:02 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-24 1def5ccfm69(暂无匿称)

    学习了

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcVAydhtcpjiaxLrZD7Eb5YnKPgf7ypGpfyl7FflFyAenvQLbib6T0LPXIhXo9SPNPXYYFFJbEgykztwJ0HQ61I3F9GxIVKWsgQ/0, createdBy=f38d2052407, createdName=周周人, createdTime=Sun Apr 23 15:33:53 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189893, encodeId=9ed81898933d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sun Apr 23 13:10:51 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189873, encodeId=85d61898e369, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:01:02 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 吴教授

    学习了

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Sun Apr 23 21:06:46 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189947, encodeId=ac9b18994ee0, content=更多的不良反应发生在小诊所小医院,没报告,没报道,, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/16/3ae1e86599052c0bb20c612346853774.jpg, createdBy=1f402044809, createdName=1881ea7c1dm, createdTime=Sun Apr 23 16:21:22 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189941, encodeId=848f1899413f, content=不良反应经常碰到,林可霉素严重过敏休克2例,幸好及时抢救,一切还好,大汗啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:01:02 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 1881ea7c1dm

    更多的不良反应发生在小诊所小医院,没报告,没报道,

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2030639, encodeId=b9882030639b7, content=<a href='/topic/show?id=5ef528884e9' target=_blank style='color:#2F92EE;'>#克林霉素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28884, encryptionId=5ef528884e9, topicName=克林霉素)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Jan 27 17:11:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787234, encodeId=6f311e87234a2, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Sun Apr 23 21:06:46 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189947, encodeId=ac9b18994ee0, content=更多的不良反应发生在小诊所小医院,没报告,没报道,, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/16/3ae1e86599052c0bb20c612346853774.jpg, createdBy=1f402044809, createdName=1881ea7c1dm, createdTime=Sun Apr 23 16:21:22 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189941, encodeId=848f1899413f, content=不良反应经常碰到,林可霉素严重过敏休克2例,幸好及时抢救,一切还好,大汗啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcVAydhtcpjiaxLrZD7Eb5YnKPgf7ypGpfyl7FflFyAenvQLbib6T0LPXIhXo9SPNPXYYFFJbEgykztwJ0HQ61I3F9GxIVKWsgQ/0, createdBy=f38d2052407, createdName=周周人, createdTime=Sun Apr 23 15:33:53 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189893, encodeId=9ed81898933d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sun Apr 23 13:10:51 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189873, encodeId=85d61898e369, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:01:02 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 周周人

    不良反应经常碰到,林可霉素严重过敏休克2例,幸好及时抢救,一切还好,大汗啊!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2030639, encodeId=b9882030639b7, content=<a href='/topic/show?id=5ef528884e9' target=_blank style='color:#2F92EE;'>#克林霉素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28884, encryptionId=5ef528884e9, topicName=克林霉素)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Jan 27 17:11:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787234, encodeId=6f311e87234a2, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Feb 09 16:11:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840517, encodeId=f50b184051ec1, content=<a href='/topic/show?id=9401204912f' target=_blank style='color:#2F92EE;'>#不良反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20491, encryptionId=9401204912f, topicName=不良反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Sat Sep 16 12:11:00 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193306, encodeId=9dc9193306c9, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Sun Apr 23 21:06:46 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189947, encodeId=ac9b18994ee0, content=更多的不良反应发生在小诊所小医院,没报告,没报道,, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/16/3ae1e86599052c0bb20c612346853774.jpg, createdBy=1f402044809, createdName=1881ea7c1dm, createdTime=Sun Apr 23 16:21:22 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189941, encodeId=848f1899413f, content=不良反应经常碰到,林可霉素严重过敏休克2例,幸好及时抢救,一切还好,大汗啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcVAydhtcpjiaxLrZD7Eb5YnKPgf7ypGpfyl7FflFyAenvQLbib6T0LPXIhXo9SPNPXYYFFJbEgykztwJ0HQ61I3F9GxIVKWsgQ/0, createdBy=f38d2052407, createdName=周周人, createdTime=Sun Apr 23 15:33:53 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189893, encodeId=9ed81898933d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sun Apr 23 13:10:51 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189873, encodeId=85d61898e369, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:01:02 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 jiuling

    学习了谢谢分享

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Sun Apr 23 21:06:46 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189947, encodeId=ac9b18994ee0, content=更多的不良反应发生在小诊所小医院,没报告,没报道,, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/16/3ae1e86599052c0bb20c612346853774.jpg, createdBy=1f402044809, createdName=1881ea7c1dm, createdTime=Sun Apr 23 16:21:22 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189941, encodeId=848f1899413f, content=不良反应经常碰到,林可霉素严重过敏休克2例,幸好及时抢救,一切还好,大汗啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcVAydhtcpjiaxLrZD7Eb5YnKPgf7ypGpfyl7FflFyAenvQLbib6T0LPXIhXo9SPNPXYYFFJbEgykztwJ0HQ61I3F9GxIVKWsgQ/0, createdBy=f38d2052407, createdName=周周人, createdTime=Sun Apr 23 15:33:53 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189893, encodeId=9ed81898933d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sun Apr 23 13:10:51 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189873, encodeId=85d61898e369, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:01:02 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 飛歌

    学习了很有用

    0

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