J Periodontol:广泛性侵袭性牙周炎患者唾液和血清中的标志物

2017-11-24 MedSci MedSci原创

宿主炎症和免疫应答在侵袭性牙周炎(AgP)中起重要作用。因此,本研究旨在评估广泛性AgP患者和牙龈炎患者或健康牙周组患者的血清和唾液中的先天免疫相关标志物钙网蛋白,集落刺激因子(CSF)-1,巨噬细胞迁移抑制因子(MIF),干扰素γ诱导的单核因子(MIG)和基质金属蛋白酶(MMP)-8。

宿主炎症和免疫应答在侵袭性牙周炎(AgP)中起重要作用。因此,本研究旨在评估广泛性AgP患者和牙龈炎患者或健康牙周组患者的血清和唾液中的先天免疫相关标志物钙网蛋白,集落刺激因子(CSF)-1,巨噬细胞迁移抑制因子(MIF),干扰素γ诱导的单核因子(MIG)和基质金属蛋白酶(MMP)-8。

方法:本研究纳入40名患者(男性17名,女性23名,平均年龄33.30±9.31岁),广泛性AgP 15例,牙龈炎15例,牙周健康10例。进行全口牙周检查,收集血清和唾液。使用酶联免疫吸附测定法测定钙网蛋白,CSF-1,MIF,MIG和MMP-8的水平。

结果:血清中钙网蛋白的平均水平是健康人群的2.06倍(P = 0.01)。 AgP患者血清MMP-8水平显着升高,分别为健康患者和牙龈炎患者的2.60倍和2.77倍(分别为P = 0.03和P = 0.009)。唾液中,AgP患者的MMP-8水平比健康者高5.66倍(P = 0.02)。血清和唾液中的CSF-1,MIF和MIG水平在组间没有显着差异。

结论:AgP患者血钙水平和MMP-8水平升高。AgP患者唾液中的MMP-8水平也增加。这些结果均支持先天免疫反应参与AgP的发病机制。

原始出处:

Ronaldo Lira-Junior, et al. Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis. Journal of Periodontology . 2017 December. doi: 10.1902/jop.2017.170287

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    2017-12-14 feather89
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    2018-10-12 hukaixun
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    2017-11-26 sunyl07
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