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CLIN CANCER RES：SAHA联合阿的平可有效诱导上消化道肿瘤细胞死亡

2018-04-27 MedSci MedSci原创

上消化道肿瘤SAHA阿的平
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CLIN CANCER RES近期发表了一篇文章，研究单药及阿的平和SAHA联合在p53野生型和突变型上消化道肿瘤细胞模型中的治疗效果。

CLIN CANCER RES近期发表了一篇文章，研究单药及阿的平和SAHA联合在p53野生型和突变型上消化道肿瘤细胞模型中的治疗效果。

作者通过ATP-Glo，细胞存活，Annexin V，comet，DSBs，qPCR和Western blot等实验方法进行研究。研究结果表明，与单药治疗相比，阿的平联合SAHA在6个上消化道肿瘤细胞模型中均可以显着降低肿瘤细胞克隆增殖，增加细胞死亡，且这一作用与p53状态无关。阿的平联合SAHA诱导的DSB DNA损伤水平最高。Western blot分析发现细胞模型中caspases-3.9和γ-H2AX活化。值得注意的是，尽管阿的平诱导野生型p53蛋白表达，阿的平联合SAHA会降低野生型p53和突变型p53的水平。此外，顺铂或吉非替尼耐药的细胞模型对这一联合治疗依然敏感。体内实验同样证明阿的平联合SAHA比单药治疗更有效抑制肿瘤生长。

文章最后认为，阿的平和SAHA促进DNA损伤，可以有效诱导肿瘤细胞死亡，与p53状态无关。顺铂或吉非替尼耐药的细胞模型依然敏感。

原始出处：
Shoumin Zhu,Zheng Chen,et al.A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers.CLIN CANCER RES.April 2018 doi:10.1158/1078-0432.CCR-17-1716

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    2018-12-03 zchen

    #上消化道#

    0

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    2018-05-02 yfjms

    学习

    0

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    2018-04-29 zhaohui6731

    #AHA#

    0

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    2018-04-29 hmwwww

    #肿瘤细胞#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1723057, encodeId=483f1e23057ef, content=<a href='/topic/show?id=0cc01998259' target=_blank style='color:#2F92EE;'>#上消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19982, encryptionId=0cc01998259, topicName=上消化道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b81833366357, createdName=zchen, createdTime=Mon Dec 03 23:32:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311172, encodeId=41d83111e2d9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed May 02 06:47:43 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267806, encodeId=26e9126e806db, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313002, encodeId=ac8a131300272, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460303, encodeId=b239146030394, content=<a href='/topic/show?id=de5015845be' target=_blank style='color:#2F92EE;'>#SAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15845, encryptionId=de5015845be, topicName=SAH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9f06287396, createdName=zexyw03, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464563, encodeId=829c146456359, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310117, encodeId=c5da31011e7c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Apr 28 15:32:36 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-29 zexyw03

    #SAH#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1723057, encodeId=483f1e23057ef, content=<a href='/topic/show?id=0cc01998259' target=_blank style='color:#2F92EE;'>#上消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19982, encryptionId=0cc01998259, topicName=上消化道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b81833366357, createdName=zchen, createdTime=Mon Dec 03 23:32:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311172, encodeId=41d83111e2d9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed May 02 06:47:43 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267806, encodeId=26e9126e806db, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313002, encodeId=ac8a131300272, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460303, encodeId=b239146030394, content=<a href='/topic/show?id=de5015845be' target=_blank style='color:#2F92EE;'>#SAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15845, encryptionId=de5015845be, topicName=SAH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9f06287396, createdName=zexyw03, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464563, encodeId=829c146456359, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310117, encodeId=c5da31011e7c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Apr 28 15:32:36 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-29 changhe715

    #消化道#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1723057, encodeId=483f1e23057ef, content=<a href='/topic/show?id=0cc01998259' target=_blank style='color:#2F92EE;'>#上消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19982, encryptionId=0cc01998259, topicName=上消化道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b81833366357, createdName=zchen, createdTime=Mon Dec 03 23:32:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311172, encodeId=41d83111e2d9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed May 02 06:47:43 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267806, encodeId=26e9126e806db, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313002, encodeId=ac8a131300272, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460303, encodeId=b239146030394, content=<a href='/topic/show?id=de5015845be' target=_blank style='color:#2F92EE;'>#SAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15845, encryptionId=de5015845be, topicName=SAH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9f06287396, createdName=zexyw03, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464563, encodeId=829c146456359, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Sun Apr 29 04:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310117, encodeId=c5da31011e7c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Apr 28 15:32:36 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-28 三生有幸9135

    学习一下谢谢分享

    0