FRONT ENDOCRINOL: 新发现!慢性疲劳综合征的病因,与甲状腺激素水平低有关

2018-03-23 Tierna 生物探索

慢性疲劳症候群是一种常见的疾病,其特征是长时间的虚弱、疲劳甚至抑郁。早在12年前,医学专家就已经发现慢性疲劳症候群的存在,但发病原因一直未被找到,直至最近,科学家们终于有了新的突破。

慢性疲劳症候群是一种常见的疾病,其特征是长时间的虚弱、疲劳甚至抑郁。早在12年前,医学专家就已经发现慢性疲劳症候群的存在,但发病原因一直未被找到,直至最近,科学家们终于有了新的突破。

近日,发表在《内分泌学前沿》杂志上的一项新研究报道,慢性疲劳综合症(CFS)症状与体内甲状腺激素水平较低有关(但可能不同于甲状腺疾病)。

对于慢性疲劳症,传统诊断依据主要基于患者症状和排除患有其他潜在疾病两种方式,通过实验室检查和体格检查诊断的方式还未有过。这一最新发现,或将为治疗那些没有得到公认治疗的虚弱性疾病铺平道路。

该研究中,由荷兰格罗宁根大学医学中心的Begona Ruiz-Nunez博士领导的研究成员比较了98名CFS患者和99名健康对照者的甲状腺功能和炎症标志物。值得注意的是,CFS患者的某些关键甲状腺激素(如三碘甲状腺原氨酸(T3)和甲状腺素(T4))的血清水平较低,但甲状腺刺激素水平正常。

进一步分析又发现,这些CFS患者的另一种称为“反向T3”或rT3的甲状腺激素水平相对较高。这可能是由于激素产生的转变,即身体倾向于将T4转换成rT3而不是产生T3。在CFS患者中发现的低T3水平与高rT3水平的生成可能意味着T3水平在组织中严重降低。此外,其他结果发现,CFS患者尿碘水平较低,炎症程度较轻(这可能反映了甲状腺功能减退症患者的症状)。

“我们研究的重要一步是,将观察到的结果持续进行两次敏感性分析验证,以检查CFS与甲状腺参数和低度炎症之间的关联强度,”Ruiz-Nunez博士说。 “这极大程度的增加了我们测试结果的准确度。”

科学家们认为,纳入患者信息,例如疾病持续时间等,可以使生化指标相互关联。此外,尽管该研究显示慢性疲劳综合征症状与低水平的关键甲状腺激素之间存在联系,但是导致CFS的详细原因仍然有待进一步探索。不过,如果该研究结果能继续被其他研究证实,它将会成为研究慢性疲劳综合征治疗方法的一个重要基础。

原始出处:
Begoa Ruiz-Nú?ez1,2, Rabab Tarasse, Emar F. Vogelaar, et al.Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study.Front. Endocrinol., 20 March 2018 | https://doi.org/10.3389/fendo.2018.00097

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    2018-03-25 tamgche
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    2018-03-25 zhouqu_8
  7. [GetPortalCommentsPageByObjectIdResponse(id=2016388, encodeId=5687201638852, content=<a href='/topic/show?id=a11369889e3' target=_blank style='color:#2F92EE;'>#甲状腺激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69889, encryptionId=a11369889e3, topicName=甲状腺激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Fri Apr 27 10:53:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670726, encodeId=bc8716e072695, content=<a href='/topic/show?id=a2d1535e141' target=_blank style='color:#2F92EE;'>#慢性疲劳综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53571, encryptionId=a2d1535e141, topicName=慢性疲劳综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a6c26750549, createdName=nian.wang1991, createdTime=Sat Jun 23 23:53:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998315, encodeId=6e27199831515, content=<a href='/topic/show?id=499c6683554' target=_blank style='color:#2F92EE;'>#激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66835, encryptionId=499c6683554, topicName=激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Aug 20 07:53:00 CST 2018, time=2018-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921218, encodeId=dcbe1921218a4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Sep 21 21:53:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260874, encodeId=621712608e488, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Sun Mar 25 01:53:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431159, encodeId=9993143115987, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Mar 25 01:53:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299377, encodeId=94492993e786, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Mar 24 23:54:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299232, encodeId=cc98299232c5, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Mar 24 09:49:48 CST 2018, time=2018-03-24, status=1, ipAttribution=)]
    2018-03-24 惠映实验室

    学习了.谢谢分享.

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2016388, encodeId=5687201638852, content=<a href='/topic/show?id=a11369889e3' target=_blank style='color:#2F92EE;'>#甲状腺激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69889, encryptionId=a11369889e3, topicName=甲状腺激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Fri Apr 27 10:53:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670726, encodeId=bc8716e072695, content=<a href='/topic/show?id=a2d1535e141' target=_blank style='color:#2F92EE;'>#慢性疲劳综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53571, encryptionId=a2d1535e141, topicName=慢性疲劳综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a6c26750549, createdName=nian.wang1991, createdTime=Sat Jun 23 23:53:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998315, encodeId=6e27199831515, content=<a href='/topic/show?id=499c6683554' target=_blank style='color:#2F92EE;'>#激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66835, encryptionId=499c6683554, topicName=激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Aug 20 07:53:00 CST 2018, time=2018-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921218, encodeId=dcbe1921218a4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Sep 21 21:53:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260874, encodeId=621712608e488, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Sun Mar 25 01:53:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431159, encodeId=9993143115987, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Mar 25 01:53:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299377, encodeId=94492993e786, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Mar 24 23:54:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299232, encodeId=cc98299232c5, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Mar 24 09:49:48 CST 2018, time=2018-03-24, status=1, ipAttribution=)]
    2018-03-24 186****0580(小山羊)

    学习了谢谢了

    0

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J Intern Med:体位性心动过速是诊断慢性疲劳综合征的有用指标吗?

背景:体位性心动过速综合征(POTS)被认为是慢性疲劳综合征(CFS)的诊断指标。 目的:本研究的目的是(i)比较CFS队列里,不符合CFS标准但伴疲劳的患者,其POTS患病率情况;(ii)评估伴POTS的CFS患者(POTS-CFS)、不伴POTS的CFS患者(non-POTS-CFS),对认知行为疗法(CBT)的活性、损害和反应。 方法:本项前瞻性队列研究在荷兰内梅亨大学医学中心进

PNAS:身心疲惫……浑浑噩噩……可能是免疫系统发生故障

慢性疲劳综合征(CFS)是一种至今病因不明的疾病,近日,斯坦福大学医学院的研究人员发现,血液中免疫分子的水平与CFS患者症状的严重程度有关。这一结果或许能为这个病因不明的疾病提供新的洞见及衡量疾病进展和评估治疗的方法。

Lancet:自我指导的分级运动是否可以改善慢性疲劳综合征?

分级运动疗法是针对慢性疲劳综合征的一种安全有效的疗法。但治疗师的数量和可得性都受限。在自我指导下的分级运动的效果和安全性如何呢?

PNAS:慢性疲劳综合征生物标记物被发现

肌痛性脑脊髓炎或慢性疲劳综合征是一种病因未知的复杂疾病。在美国,该病的发病人数在一百万以上,而在全球,该疾病有数百万患者。之前的报导显示,肌痛脑脊髓炎或慢性疲劳综合征患者有炎症的迹象,但是现有的数据量非常有限,且相互矛盾。