Heart：叶酸和维生素B12缺乏与心衰患者贫血有关吗？

2014-11-04 cath 编译医学论坛网

多国学者们对慢性心力衰竭(简称心衰)与叶酸和维生素B12水平的相关性进行了研究。结果表明，在这些患者中，维生素B12和叶酸缺乏相对罕见。由于平均红细胞容积与叶酸或维生素B12水平无显著相关性，因此这种细胞指数应慎用于慢性心衰患者贫血的鉴别诊断。与铁缺乏想反，维生素B12和叶酸水平不与上述诊断具有相关性。该国际汇集队列研究纳入了610例慢性心衰患者，这些患者平均年龄为68±12岁，中位血N-末端

多国学者们对慢性心力衰竭(简称心衰)与叶酸和维生素B₁₂水平的相关性进行了研究。结果表明，在这些患者中，维生素B12和叶酸缺乏相对罕见。由于平均红细胞容积与叶酸或维生素B₁₂水平无显著相关性，因此这种细胞指数应慎用于慢性心衰患者贫血的鉴别诊断。与铁缺乏想反，维生素B₁₂和叶酸水平不与上述诊断具有相关性。

该国际汇集队列研究纳入了610例慢性心衰患者，这些患者平均年龄为68±12岁，中位血N-末端脑钠肽水平为1801 pg/mL，左室射血分数(LVEF)>45%的患者百分比为13%。主要转归指标为全因死亡。

结果显示，血清维生素B₁₂(<200 pg/mL)、叶酸(<4.0 ng/mL)和铁缺乏(血清铁蛋白<100 µg/L或100–299 µg/L转铁蛋白<20%)的百分比分别为5%、4% 和58%。

未观察到平均红细胞容积与与叶酸或维生素B₁₂水平的显著相关性。叶酸水平较低与健康相关的生活质量受损有关(P=0.029)。在中位随访的2.10年中， 254例患者死亡。多变量比例风险模型分析显示，叶酸和维生素B₁₂水平与诊断无相关性。

原始出处：

van der Wal HH1, Comin-Colet J2, Klip IT1, Enjuanes C2, Grote Beverborg N1, Voors AA1, Banasiak W3, van Veldhuisen DJ1, Bruguera J2, Ponikowski P4, Jankowska EA4, van der Meer P1.Vitamin B12 and folate deficiency in chronic heart failure.Heart. 2014 Oct 16. pii: heartjnl-2014-306022. doi: 10.1136/heartjnl-2014-306022. [Epub ahead of print]

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2016-01-03 三三五五

棒

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2015-05-04 12498adam40暂无昵称

#维生素B12缺乏#

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2014-11-06 zhaojie88

#ART#

37 0
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2014-11-06 yuanming7

#心衰患者#

36 0
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2014-11-06 bnjfx@127.com

#维生素B12#

46 0
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2014-11-06 马龙

#维生素B#

30 0
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2014-11-06 爆笑小医

#HEART#

31 0

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