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AAN 2014：自身免疫性脑炎临床研究进展

2014-05-07 复旦大学附属华山医院神经科 陈向军 赵重波 医学论坛网

AAN神经免疫病
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Dalmau等在C57/BL6小鼠脑室腔内注射抗NMDAR脑炎患者脑脊液后，观察到动物海马区NMDA受体因受抗体攻击而数量减少，从而导致小鼠记忆与行为学异常。这给抗NMDAR脑炎的发病机制提供了新的证据。Tobin等报告一类针对神经元Kv4.2钾离子通道调节亚单位二肽基肽酶样蛋白(Dipeptidyl-Peptidase-like Protein, DPPX)的抗体介导的新型自身免疫性脑炎，其临床

Dalmau等在C57/BL6小鼠脑室腔内注射抗NMDAR脑炎患者脑脊液后，观察到动物海马区NMDA受体因受抗体攻击而数量减少，从而导致小鼠记忆与行为学异常。这给抗NMDAR脑炎的发病机制提供了新的证据。

Tobin等报告一类针对神经元Kv4.2钾离子通道调节亚单位二肽基肽酶样蛋白(Dipeptidyl-Peptidase-like Protein, DPPX)的抗体介导的新型自身免疫性脑炎，其临床表现为脑炎综合征、自主神经功能障碍与高兴奋性表现(癫痫发作、肌阵挛、兴奋躁动与腹泻)。抗DPPX抗体检测有助于早期诊断这类可治性疾病。








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    2014-07-26 chen111111

    临床上检测各种自身免疫抗体的方法？

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=10637, encodeId=2f191063e34, content=临床上检测各种自身免疫抗体的方法？, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2d2103784, createdName=chen111111, createdTime=Sat Jul 26 10:20:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343553, encodeId=efbc1343553a1, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Fri May 09 00:36:00 CST 2014, time=2014-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380422, encodeId=8a14138042228, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Fri May 09 00:36:00 CST 2014, time=2014-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446420, encodeId=b5d31446420c8, content=<a href='/topic/show?id=2e3016e437' target=_blank style='color:#2F92EE;'>#AAN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1674, encryptionId=2e3016e437, topicName=AAN)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIt6X4iaHW8bDticcBSHUibNWk4Koe2icf0pdIOicSueicR3AKmviaSNPHkf9bCEicRK0anXEu3DjolU2EmkQ/132, createdBy=98ca5217513, createdName=bluefate123, createdTime=Fri May 09 00:36:00 CST 2014, time=2014-05-09, status=1, ipAttribution=)]
    2014-05-09 ms1779634646866130

    #脑炎#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=10637, encodeId=2f191063e34, content=临床上检测各种自身免疫抗体的方法？, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2d2103784, createdName=chen111111, createdTime=Sat Jul 26 10:20:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343553, encodeId=efbc1343553a1, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Fri May 09 00:36:00 CST 2014, time=2014-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380422, encodeId=8a14138042228, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Fri May 09 00:36:00 CST 2014, time=2014-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446420, encodeId=b5d31446420c8, content=<a href='/topic/show?id=2e3016e437' target=_blank style='color:#2F92EE;'>#AAN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1674, encryptionId=2e3016e437, topicName=AAN)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIt6X4iaHW8bDticcBSHUibNWk4Koe2icf0pdIOicSueicR3AKmviaSNPHkf9bCEicRK0anXEu3DjolU2EmkQ/132, createdBy=98ca5217513, createdName=bluefate123, createdTime=Fri May 09 00:36:00 CST 2014, time=2014-05-09, status=1, ipAttribution=)]
    2014-05-09 mashirong

    #研究进展#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=10637, encodeId=2f191063e34, content=临床上检测各种自身免疫抗体的方法？, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2d2103784, createdName=chen111111, createdTime=Sat Jul 26 10:20:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343553, encodeId=efbc1343553a1, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Fri May 09 00:36:00 CST 2014, time=2014-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380422, encodeId=8a14138042228, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Fri May 09 00:36:00 CST 2014, time=2014-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446420, encodeId=b5d31446420c8, content=<a href='/topic/show?id=2e3016e437' target=_blank style='color:#2F92EE;'>#AAN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1674, encryptionId=2e3016e437, topicName=AAN)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIt6X4iaHW8bDticcBSHUibNWk4Koe2icf0pdIOicSueicR3AKmviaSNPHkf9bCEicRK0anXEu3DjolU2EmkQ/132, createdBy=98ca5217513, createdName=bluefate123, createdTime=Fri May 09 00:36:00 CST 2014, time=2014-05-09, status=1, ipAttribution=)]
    2014-05-09 bluefate123

    #AAN#

    0

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