STM:反转:化疗还是杀死癌细胞的更佳选择?新研究说NO!

2017-07-06 Vanora 转化医学网

乳腺癌是女性最常见的恶性肿瘤之一,其主要治疗方法为手术治疗及化疗。在英国,每年大约有55,000名女性被诊断患有乳腺癌,约11,000人将因其而死亡。其中许多人接受了术前化疗。

乳腺癌是女性最常见的恶性肿瘤之一,其主要治疗方法为手术治疗及化疗。在英国,每年大约有55,000名女性被诊断患有乳腺癌,约11,000人将因其而死亡。其中许多人接受了术前化疗。

尽管术前化疗可以短期内缩小肿瘤,但最新的研究表明,化疗还可能会引起癌细胞在体内的扩散,甚至引起侵袭性更高的肿瘤。一旦癌灶发生远处转移,预后将十分悲观。

纽约Yeshiva大学Albert Einstein医学院的George Karagiannis教授发现,术前化疗在使肿瘤缩小的同时,也为肿瘤扩散进入血液系统提供了途径,使其更容易远处转移。研究发现,接受两种常见化疗药物的患者血管上供癌细胞转移的“门窗”数量明显增多。同时还发现,在接受乳腺癌化疗的小鼠中,身体和肺部的癌细胞数量明显增加。

George Karagiannis教授说,此研究的目的并不是阻止患者接受治疗,而是建议创造一种更好地监测接受化疗的患者肿瘤移动的方法。目前,其中一种方法是在少量术前化疗后获得少量的肿瘤组织。“如果我们观察到标记评分增加,我们建议先停止化疗并进行手术,然后再进行术后化疗。”

然而,这并不是首次发现化疗可以引发癌症转移的研究。西雅图Fred Hutchinson癌症研究中心在2012年已发现化疗可以促进肿瘤生长。

生物学教授Peter Nelson说,理论上化疗是杀死癌细胞的最佳选择。一定剂量的有毒药物与实验皿中的肿瘤混合,肿瘤无法生存或传播。但是杀死肿瘤所需的剂量对于患者同样是是致命的。

因此,在化疗的过程中,医生必须施用较低的剂量。这种做法有两个不利之处。首先,它允许一些肿瘤细胞生存,变得耐药,并传播到其他器官。第二,它依旧对人体有害。

一旦癌症发生转移,往往具有更强的侵蚀性和抗治疗性,因此难以治疗,预后十分悲观。所以如何更好的发挥化疗的有利之处并降低其副作用成为目前亟待解决的问题。

Karagiannas教授说:“我们正在规划更广泛的试验来解决这个问题。在这项研究中,我们仅研究了化疗诱导的乳腺癌癌细胞传播。我们正在研究其他类型的癌症,看看是否会引起类似的作用。”

原始出处:

George S. Karagiannis, Jessica M. Pastoriza, et al. Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. Science Translational Medicine  05 Jul 2017: Vol. 9, Issue 397, eaan0026 DOI: 10.1126/scitranslmed.aan0026

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  1. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Sat Jul 08 08:30:49 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219557, encodeId=f3c821955e16, content=有精准杀死癌细胞的靶向药该多好呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplWkAYEyDuFN0IVp2TmfJ8yY2YXYZaI63xAt8Np2LyUaYMyKIHU9KGtxW6JfYZEC4LQgHibccufT5U/0, createdBy=40971605465, createdName=foreverlove, createdTime=Fri Jul 07 15:52:49 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219544, encodeId=0ec121954404, content=有待跟进!, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97e42072173, createdName=1861f05a42m, createdTime=Fri Jul 07 14:30:02 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219483, encodeId=509721948391, content=因为化疗并不能完全杀死肿瘤细胞,致耐药转移的发生,大体与细菌对抗生素耐药的机理差不多。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/18/f1f89ef4b653ca8843378cfb1a428f68.jpg, createdBy=e4ba2058756, createdName=1391ed65ebm, createdTime=Fri Jul 07 11:10:57 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219460, encodeId=63ca21946033, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, 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    2017-08-18 gdsun
  2. 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    2017-07-15 李东泽

    很好,不错,以后会多学习

    0

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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97e42072173, createdName=1861f05a42m, createdTime=Fri Jul 07 14:30:02 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219483, encodeId=509721948391, content=因为化疗并不能完全杀死肿瘤细胞,致耐药转移的发生,大体与细菌对抗生素耐药的机理差不多。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/18/f1f89ef4b653ca8843378cfb1a428f68.jpg, createdBy=e4ba2058756, createdName=1391ed65ebm, createdTime=Fri Jul 07 11:10:57 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219460, encodeId=63ca21946033, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Jul 07 09:38:47 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2017-07-08 1070030296

    很早以前我就在想这个问题,后面中医老师还特地讲了化疗的后果。。。

    0

  4. 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likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Jul 07 09:38:47 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2017-07-08 yxch36
  5. 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    2017-07-08 李东泽

    很好,不错,以后会多学习

    0

  6. 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97e42072173, createdName=1861f05a42m, createdTime=Fri Jul 07 14:30:02 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219483, encodeId=509721948391, content=因为化疗并不能完全杀死肿瘤细胞,致耐药转移的发生,大体与细菌对抗生素耐药的机理差不多。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/18/f1f89ef4b653ca8843378cfb1a428f68.jpg, createdBy=e4ba2058756, createdName=1391ed65ebm, createdTime=Fri Jul 07 11:10:57 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219460, encodeId=63ca21946033, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Jul 07 09:38:47 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2017-07-08 hfuym10906

    学习了?。。。。

    0

  7. 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topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sat Jul 08 11:21:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219856, encodeId=7be0219856e4, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Jul 08 08:59:43 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219836, encodeId=1ec92198362c, content=学习了?。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Sat Jul 08 08:30:49 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219557, encodeId=f3c821955e16, content=有精准杀死癌细胞的靶向药该多好呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplWkAYEyDuFN0IVp2TmfJ8yY2YXYZaI63xAt8Np2LyUaYMyKIHU9KGtxW6JfYZEC4LQgHibccufT5U/0, createdBy=40971605465, createdName=foreverlove, createdTime=Fri Jul 07 15:52:49 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219544, encodeId=0ec121954404, content=有待跟进!, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97e42072173, createdName=1861f05a42m, createdTime=Fri Jul 07 14:30:02 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219483, encodeId=509721948391, content=因为化疗并不能完全杀死肿瘤细胞,致耐药转移的发生,大体与细菌对抗生素耐药的机理差不多。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/18/f1f89ef4b653ca8843378cfb1a428f68.jpg, createdBy=e4ba2058756, createdName=1391ed65ebm, createdTime=Fri Jul 07 11:10:57 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219460, encodeId=63ca21946033, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Jul 07 09:38:47 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2017-07-07 foreverlove

    有精准杀死癌细胞的靶向药该多好呀

    0

  8. 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topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sat Jul 08 11:21:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219856, encodeId=7be0219856e4, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Jul 08 08:59:43 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219836, encodeId=1ec92198362c, content=学习了?。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Sat Jul 08 08:30:49 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219557, encodeId=f3c821955e16, content=有精准杀死癌细胞的靶向药该多好呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplWkAYEyDuFN0IVp2TmfJ8yY2YXYZaI63xAt8Np2LyUaYMyKIHU9KGtxW6JfYZEC4LQgHibccufT5U/0, createdBy=40971605465, createdName=foreverlove, createdTime=Fri Jul 07 15:52:49 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219544, encodeId=0ec121954404, content=有待跟进!, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97e42072173, createdName=1861f05a42m, createdTime=Fri Jul 07 14:30:02 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219483, encodeId=509721948391, content=因为化疗并不能完全杀死肿瘤细胞,致耐药转移的发生,大体与细菌对抗生素耐药的机理差不多。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/18/f1f89ef4b653ca8843378cfb1a428f68.jpg, createdBy=e4ba2058756, createdName=1391ed65ebm, createdTime=Fri Jul 07 11:10:57 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219460, encodeId=63ca21946033, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Jul 07 09:38:47 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2017-07-07 1861f05a42m

    有待跟进!

    0

  9. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Sat Jul 08 08:30:49 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219557, encodeId=f3c821955e16, content=有精准杀死癌细胞的靶向药该多好呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplWkAYEyDuFN0IVp2TmfJ8yY2YXYZaI63xAt8Np2LyUaYMyKIHU9KGtxW6JfYZEC4LQgHibccufT5U/0, createdBy=40971605465, createdName=foreverlove, createdTime=Fri Jul 07 15:52:49 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219544, encodeId=0ec121954404, content=有待跟进!, beContent=null, objectType=article, 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likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Jul 07 09:38:47 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2017-07-07 1391ed65ebm

    因为化疗并不能完全杀死肿瘤细胞,致耐药转移的发生,大体与细菌对抗生素耐药的机理差不多。学习了。

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1677997, encodeId=f6e816e7997e6, content=<a href='/topic/show?id=29a8168130f' target=_blank style='color:#2F92EE;'>#STM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16813, encryptionId=29a8168130f, topicName=STM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d76127619556, createdName=gdsun, createdTime=Fri Aug 18 15:21:00 CST 2017, time=2017-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222672, encodeId=e9a72226e260, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Jul 15 20:15:51 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220015, encodeId=973d220015e2, content=很早以前我就在想这个问题,后面中医老师还特地讲了化疗的后果。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161015/IMG5801C4A734E137989.jpg, createdBy=51871947992, createdName=1070030296, createdTime=Sat Jul 08 18:28:48 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252292, encodeId=24241252292d1, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sat Jul 08 11:21:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219856, encodeId=7be0219856e4, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Jul 08 08:59:43 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219836, encodeId=1ec92198362c, content=学习了?。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Sat Jul 08 08:30:49 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219557, encodeId=f3c821955e16, content=有精准杀死癌细胞的靶向药该多好呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplWkAYEyDuFN0IVp2TmfJ8yY2YXYZaI63xAt8Np2LyUaYMyKIHU9KGtxW6JfYZEC4LQgHibccufT5U/0, createdBy=40971605465, createdName=foreverlove, createdTime=Fri Jul 07 15:52:49 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219544, encodeId=0ec121954404, content=有待跟进!, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97e42072173, createdName=1861f05a42m, createdTime=Fri Jul 07 14:30:02 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219483, encodeId=509721948391, content=因为化疗并不能完全杀死肿瘤细胞,致耐药转移的发生,大体与细菌对抗生素耐药的机理差不多。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/18/f1f89ef4b653ca8843378cfb1a428f68.jpg, createdBy=e4ba2058756, createdName=1391ed65ebm, createdTime=Fri Jul 07 11:10:57 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219460, encodeId=63ca21946033, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Jul 07 09:38:47 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2017-07-07 李东泽

    很好,不错,以后会多学习

    0

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