Lancet:与电子烟相关的持续性肺损伤的特征与治疗

2019-11-11 MedSci MedSci原创

研究认为,与电子烟或蒸汽电子烟相关的肺损伤是一种新疾病,可导致严重的肺损伤以及体质和胃肠道症状。大部分患者在接受抗生素和类固醇治疗后症状缓解但许多患者仍有残余症状。

2019年3月,美国陆续报道了与电子烟相关的持续性肺损伤(也称为E-VALI或VALI)病例,但该疾病的病因、诊断、治疗和病程尚不清楚。

在这项多中心、前瞻性、观察性、队列研究中,研究人员收集了2019年6月27日至10月4日在美国犹他州发现的所有与电子香烟或蒸汽电子烟相关的肺损伤患者的数据。研究人员从图表审查和患者的访谈中提取了患者陈述、治疗和短期随访(出院后2周)的数据。

研究期间,总计接收了60名与电子烟或蒸汽电子烟有关的肺损伤病例。60人中有33人(55%)进住了重症监护室(ICU)。60名患者中有53人(88%)出现体质症状,59人(98%)出现呼吸系统症状,54例(90%)出现肠道症状。60例患者中有54例(90%)接受抗生素治疗,57例(95%)接受类固醇治疗。60名患者中有6名(10%)在2周内再次入院,其中3名(50%)因吸食或使用电子烟而复发。26例接受2周内随访的患者中,尽管所有患者的临床和放射学检查有所改善,但许多患者的胸片(67%)和肺功能检查(67%)存在异常。2名患者死亡,与电子烟或吸电子烟相关的肺损伤被认为是一个促成因素,但不是两人死亡的主要原因。

研究认为,与电子烟或蒸汽电子烟相关的肺损伤是一种新疾病,可导致严重的肺损伤以及体质和肠道症状。大部分患者在接受抗生素和类固醇治疗后症状缓解但许多患者仍有残余症状。

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    2020-02-22 howi
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    2019-11-13 tastas

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