Eur J Heart Fail:急性心力衰竭患者出院时接受心衰口服药物治疗预后更好!

2018-03-01 xing.T MedSci原创

由此可见,在出院时接受HFOTs治疗与AHF患者更好的生存结局相关。

急性心力衰竭(AHF)后出院前接受心力衰竭口服治疗(HFOTs),包括β受体阻滞剂(BB)、肾素血管紧张素系统抑制剂(RASi)和盐皮质激素受体拮抗剂,可能改善患者预后。近日,心血管领域权威杂志European Journal of Heart Failure上发表了一篇研究文章,研究人员假设在出院时接受HFOTs可能与更好的出院生存率相关。

研究人群由19980例AHF患者组成,该研究的主要和次要结局分别为90天和1年的全因死亡率。研究人员采用单变量和协变量调整后的Cox比例风险回归模型估计了整个人群和倾向性评分匹配后人群的生存率。

研究人员发现整个人群和匹配队列在未调整和调整分析中出院时HFOTs与没有多余的死亡密切相关。在匹配的队列中,出院时BB和RASi都与较低的90天死亡风险相关,相比于各自对照组[风险比(HR)为0.56,95%可信区间(CI)为0.46-0.69;以及HR为0.53,95%CI为0.42-0.66]。出院时服用BB和RASi与90天死亡之间有利的相关性存在于许多亚组中,包括左室射血分数减少和正常的患者,并且持续到出院后1年。联合服用RASi和BB比单独服用RASi或BB与死亡风险降低更相关。

由此可见,在出院时接受HFOTs治疗与AHF患者更好的生存结局相关。

原始出处:

Etienne Gayat, et al. Heart failure oral therapies at discharge are associated with better outcome in acute heart failure: a propensity-score matched study. 2018. http://onlinelibrary.wiley.com/doi/10.1002/ejhf.932/full

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    2019-01-08 gdsun
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    2018-03-02 zhaojie88
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    2018-03-02 slcumt

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