J Cell Physiol:组蛋白去乙酰化酶抑制剂AR-42在Y79细胞中通过诱导细胞凋亡和细胞周期停滞而发挥抗肿瘤作用

2019-05-20 不详 网络

南昌大学第三附属医院眼科的Duan S等人近日在J Cell Physiol杂志上发表了一项研究工作。视网膜母细胞瘤(RB)是儿童时期最常见的眼内恶性肿瘤。AR-42是新发现的一类苯基丁酸酯衍生的组蛋白去乙酰化酶的抑制剂成员,对许多癌症都有抗肿瘤作用。在本研究中,他们最初评估了AR-42对RB细胞的作用,并探讨了该疾病的潜在治疗机制。

南昌大学第三附属医院眼科的Duan S等人近日在J Cell Physiol杂志上发表了一项研究工作。视网膜母细胞瘤(RB)是儿童时期最常见的眼内恶性肿瘤。AR-42是新发现的一类苯基丁酸酯衍生的组蛋白去乙酰化酶的抑制剂成员,对许多癌症都有抗肿瘤作用。在本研究中,他们最初评估了AR-42对RB细胞的作用,并探讨了该疾病的潜在治疗机制。

他们的研究结果发现,AR-42在低浓度下具有较强的抗肿瘤作用。AR-42通过抑制细胞活力、阻断细胞周期、刺激体外细胞凋亡等方式,抑制小鼠皮下肿瘤RB的生长。此外,在用AR-42处理的Y79细胞中,AKT /核因子-κB信号传导途径被破坏。

总之,他们提出AR-42可能是RB的潜在药物治疗靶标。

原文出处:

Duan, S., et al., Histone deacetylase inhibitor, AR-42, exerts antitumor effects by inducing apoptosis and cell cycle arrest in Y79 cells. J Cell Physiol, 2019.

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createdBy=ad9f79, createdName=般若傻瓜, createdTime=Fri Dec 20 02:15:00 CST 2019, time=2019-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871275, encodeId=963118e127599, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Jun 04 10:15:00 CST 2019, time=2019-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961558, encodeId=f9ea1961558ac, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Jul 31 15:15:00 CST 2019, time=2019-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788917, encodeId=ffb41e8891784, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Oct 31 22:15:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037271, encodeId=04df203e27156, content=<a href='/topic/show?id=d0aae7834e6' target=_blank style='color:#2F92EE;'>#细胞周期停滞#</a>, beContent=null, objectType=article, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340296, encodeId=c51e1340296f7, content=<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/EFCEF19303EB52B3F41B30C45995AF2C/100, createdBy=8e712500159, createdName=ms8538335253054589, createdTime=Wed May 22 07:15:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
    2019-07-31 维他命
  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340296, encodeId=c51e1340296f7, content=<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/EFCEF19303EB52B3F41B30C45995AF2C/100, createdBy=8e712500159, createdName=ms8538335253054589, createdTime=Wed May 22 07:15:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
  6. 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channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77834, encryptionId=d0aae7834e6, topicName=细胞周期停滞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat Sep 28 15:15:00 CST 2019, time=2019-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1851997, encodeId=03ed185199e4a, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Thu Sep 19 07:15:00 CST 2019, time=2019-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780005, encodeId=e88d1e8000532, content=<a 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  7. 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href='/topic/show?id=1e6c2e148c' target=_blank style='color:#2F92EE;'>#AR-42#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2714, encryptionId=1e6c2e148c, topicName=AR-42)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5462342, createdName=sunmin0219, createdTime=Sun Jan 26 05:15:00 CST 2020, time=2020-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287522, encodeId=ba3c128e52228, content=<a href='/topic/show?id=1c48e783278' target=_blank style='color:#2F92EE;'>#细胞周期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77832, encryptionId=1c48e783278, topicName=细胞周期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Wed May 22 07:15:00 CST 2019, time=2019-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340296, encodeId=c51e1340296f7, content=<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/EFCEF19303EB52B3F41B30C45995AF2C/100, createdBy=8e712500159, createdName=ms8538335253054589, createdTime=Wed May 22 07:15:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
    2019-09-19 jklm09
  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340296, encodeId=c51e1340296f7, content=<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/EFCEF19303EB52B3F41B30C45995AF2C/100, createdBy=8e712500159, createdName=ms8538335253054589, createdTime=Wed May 22 07:15:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
    2020-01-26 sunmin0219
  9. 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  10. 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