Sci Rep:无症状性颅外动脉狭窄与心脑血管风险增加相关

2016-10-31 MedSci MedSci原创

无症状性颅外动脉狭窄(ECAS)是卒中事件的危险因素之一,但目前尚不清楚ECAS是否预测心脑血管疾病的作用,尤其是在中国。本研究研究ECAS、颈动脉斑块及颈动脉内膜中层厚度与心脑血管疾病发生的相关性。共有5440名受试者,其中在基线364例患者表现为无症状,185例发生了最后的血管事件(脑梗塞、脑出血、蛛网膜下腔出血、冠心病和因血管疾病死亡)。在随访过程中,ECAS、颈动脉斑块及其不稳定性,增加的

无症状性颅外动脉狭窄(ECAS)是卒中事件的危险因素之一,但目前尚不清楚ECAS是否预测心脑血管疾病的作用,尤其是在中国。本研究探究了ECAS、颈动脉斑块及颈动脉内膜中层厚度与心脑血管疾病发生的相关性。

共有5440名受试者,其中在基线364例患者表现为无症状,185例发生了最后的血管事件(脑梗塞、脑出血、蛛网膜下腔出血、冠心病和因血管疾病死亡)。在随访过程中,ECAS、颈动脉斑块及其不稳定性,增加的CIMT与血管事件显著相关。校正相关的心血管危险因素,ECAS仍然与血管事件发生的密切关系,尤其是脑梗塞(HR 2.101;95%CI:1.027-4.298;P  = 0.042)。

研究者观察到ECAS与心脑血管疾病的发生之间有明显的相关性,尤其是脑梗塞事件。颈动脉斑块及其稳定性和增加CIMT都与血管事件的发生相关。研究结果为ECAS在血管事件发生中的重要作用提供直接的证据。

原始出处:

Wang D, Wang J,et al. Asymptomatic Extracranial Artery Stenosis and the Risk of Cardiovascular and Cerebrovascular Diseases. Sci Rep. 2016 Sep 21


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