Ann Intern Med:疑似感染患者快速序贯器官衰竭评估预测死亡的准确性!

2018-02-07 xing.T MedSci原创

由此可见,qSOFA对短期死亡的敏感性低,特异性适中。SIRS标准的敏感性优于qSOFA,支持其用于筛查患者和作为开始治疗的指征。

快速序贯器官衰竭评估(qSOFA)已被提出用于预测疑似感染患者的死亡率。近日,内科学权威杂志Annals of Internal Medicine上发表了一篇研究文章,研究人员旨在总结qSOFA预测疑似感染成人的死亡率准确性,并与全身炎症反应综合征(SIRS)标准进行比较。

研究人员检索了四个数据库,检索时间从数据库成立之时到2017年11月。研究人员使用qSOFA进行英语语言研究,以预测重症监护室(ICU),急诊科(ED)或医院病房中疑似感染的成年患者的死亡率(住院期,28天或30天)。两名研究者独立地提取数据并使用标准标准评估研究质量。

该研究纳入了38项研究(n=385333)。qSOFA与死亡率相关,合并的灵敏度为60.8%(95%可信区间为51.4%-69.4%)和特异性为72.0%(95%可信区间为63.4%-79.2%)。SIRS标准合并的灵敏度为88.1%(95%可信区间为82.3%-92.1%)和特异性为25.8%(95%可信区间为17.1%-36.9%)。在ICU人群中qSOFA的敏感性(87.2%,95%可信区间为75.8%-93.7%)高于非ICU人群(51.2%,95%可信区间为43.6%-58.7%)。qSOFA在非ICU人群中合并的特异性(79.6%[95%可信区间为73.3%-84.7%])高于ICU人群(33.3%[95%可信区间为23.8%-44.4%])。

由此可见,qSOFA对短期死亡的敏感性低,特异性适中。SIRS标准的敏感性优于qSOFA,支持其用于筛查患者和作为开始治疗的指征。

原始出处:


Shannon M. Fernando,et al. Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis. Ann Intern Med 2018. http://annals.org/aim/article-abstract/2671919/prognostic-accuracy-quick-sequential-organ-failure-assessment-mortality-patients-suspected

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