Allergy:研究揭示与过敏性鼻炎相关的表观遗传变化!

2017-08-07 佚名 来宝网

根据7月29日在Allergy发表的一项研究,草花粉诱导的过敏性鼻炎者在接触草花粉后3小时内会发生表观遗传变化。

根据7月29日在Allergy发表的一项研究,草花粉诱导的过敏性鼻炎者在接触草花粉后3小时内会发生表观遗传变化。

加拿大金斯敦女王大学的Michelle L. North博士及其同事在连续两天检查了38名过敏症患者的全基因组表型遗传变化和接触草花粉的8个对照组,共3小时。 Infinium Methylation 450K阵列在基线和外周血三小时评估DNA甲基化。

研究人员发现,有42个位点显示出显着的DNA甲基化变化≥2%。焦磷酸测序反应暴露时,验证了类胰蛋白酶γ1(TPSG1),schlafen 12(SLFN12)和粘蛋白4(MUC4)的DNA甲基化变化。症状与SLFN12 DNA甲基化显着相关(P <0.05),基线DNA甲基化模式可预测草花粉变应原暴露后症状严重程度(P <0.05)。在单独的验证队列中,鼻刷中MUC4 DNA甲基化的变化与鼻吸气流速下降相关(P = 0.034),MUC4基因表达显着增加(P <0.0001)。

作者写道:“总而言之,这项研究表明,草粉花粉诱导的过敏性鼻炎者在暴露于草花粉后3小时内会发生表观遗传变化。 “这项研究还强调了血液中表观遗传变化可能表明靶组织有类似修饰的可能性,而且可能由于环境暴露引起的预先存在的表观遗传标记可能会对随后的变应原反应产生影响。

原始出处:
North ML, Jones MJ, MacIsaac JL,et al.Blood and Nasal Epigenetics Correlate to Allergic Rhinitis Symptom Development in the Environmental Exposure Unit.Allergy. 2017 Jul 29. doi: 10.1111/all.13263. [Epub ahead of print]

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    2017-08-09 膀胱癌
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    2017-08-07 139****5926

    好好文章学习了

    0

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