Gastroenterology:饮食成分对肠道菌群、肠通透性以及肠道炎症性疾病的影响

2017-11-24 zhangfan MedSci原创

研究发现不同营养物质对肠通透性、肠道微生物密度和肠道炎症的发展存在不同程度的影响,这一结果再次强调了平衡膳食成分对维持肠道稳态的重要性

日常饮食对肠道菌群、粘膜炎症或炎症性肠病的影响尚未被完全阐明。近日研究人员通过小鼠模型考察了膳食成分、营养元素与肠道微生物之间的关系,并量化膳食营养元素对结肠炎、肠道健康和微生物的效应。

研究采用C56BL/6J无特定病原体体(SPF)和无菌(GF)小鼠,进行不同浓度的蛋白质、脂肪、易消化碳水化合物和不易消化碳水化合物(纤维素)饲料喂养,1周后使用葡聚糖硫酸钠(DSS)诱导结肠炎。根据体重变化考察小鼠疾病程度,考察小鼠标记葡聚糖的血药浓度测定肠道通透性,利用16S rDNA测序分析粪便菌群含量,对小鼠结肠组织进行转录组分析。

粪便菌群随饮食存在变化,蛋白质和纤维素饮食对结肠炎的发生影响显著。研究发现,在SPF小鼠中车前子,果胶和纤维素纤维可缓解小鼠结肠炎症状的严重程度而甲基纤维素会加重病情。蛋白饮食可增加SPF小鼠粪便菌群密度并加重结肠炎症状,但对GF小鼠和给予抗生素治疗的小鼠无影响。亚麻纤维通过微生物依赖或非依赖途径降低结肠炎的严重程度。饮食中酪蛋白以及亚麻纤维含量变化对肠道菌群含量、肠道通透性以及结肠炎严重程度的影响最为显著。

研究发现不同营养物质对肠通透性、肠道微生物密度和肠道炎症的发展存在不同程度的影响,这一结果再次强调了平衡膳食成分对维持肠道稳态的重要性。

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    2018-11-22 yaxin132

    学习了!

    0

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    2017-12-30 许安
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547101, encodeId=446e154e101d4, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Sun Nov 26 00:59:00 CST 2017, time=2017-11-26, status=1, ipAttribution=)]
    2018-03-20 zhmscau
  4. 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  5. 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  6. 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  7. 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