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Diabetologia：多肽偶联的纳米颗粒在“人源化”的HLA-转基因小鼠中诱导耐受并抑制1型糖尿病中致糖尿病CD8+T细胞应答

2017-12-31 MedSci MedSci原创

糖尿病小鼠模型
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近日，国际杂志 《Diabetologia》上在线发表一项关于多肽偶联的纳米颗粒在“人源化”的HLA-转基因小鼠中诱导耐受性并抑制1型糖尿病中致糖尿病CD8+T细胞应答的研究。 诱导抗原特异性免疫耐受性可以在NOD小鼠模型中提供具有前景的免疫疗法，但是成功转化为人类1型糖尿病的条件是有限的。在这项研究中，研究人员将500 nm羧化聚苯乙烯珠（PSB）与免疫显性HLA-A * 02：01限制性

近日，国际杂志 《Diabetologia》上在线发表一项关于多肽偶联的纳米颗粒在“人源化”的HLA-转基因小鼠中诱导耐受性并抑制1型糖尿病中致糖尿病CD8+T细胞应答的研究。

诱导抗原特异性免疫耐受性可以在NOD小鼠模型中提供具有前景的免疫疗法，但是成功转化为人类1型糖尿病的条件是有限的。在这项研究中，研究人员将500 nm羧化聚苯乙烯珠（PSB）与免疫显性HLA-A * 02：01限制性表位（肽-PSB ）的混合物共价连接，这些表位可能在人类中具有高度临床相关性，因为它们促进免疫耐受， 然后研究了纳米颗粒 - 肽复合物对T细胞耐受性的影响。

研究人员将HLA-A * 02：01限制性表位的PSB- 偶联混合物通过静脉内注射给予HHD II小鼠。在NODβ2M null小鼠中验证了延迟疾病进程的效果。在患有1型糖尿病的个体中验证了用肽-PSB治疗的糖尿病性HLA-A * 02：01限制性细胞毒性淋巴细胞（CTL）应答。

研究表明肽-PSB可以诱导HHD II小鼠的抗原特异性耐受。保护性免疫机制是通过CD4 + CD25 +调节性T细胞的功能，抑制性T细胞活化和T细胞无效能而介导的。此外，肽-PSB 通过快速产生CD169 +巨噬细胞衍生的CC基序趋化因子22（CCL22）诱导调节性T细胞和CD11c +树突细胞的活化和积聚。肽-PSB还防止了“人源化”NODβ2M null中的糖尿病和抑制1型糖尿病患者的致病性CTL应答。

研究结果首次证明了使用多肽-PSB复合物诱导T细胞耐受并终止自身免疫过程的可能性。这些发现提供了1型糖尿病中抗原特异性耐受策略有前景的平台，并强调了嗜金属巨噬细胞介导肽-PSB诱导的免疫耐受所需的早期细胞-细胞相互作用的机制。

原始出处：

Xinyu Xu, Lingling Bian, Min Shen，et al. Multipeptide-coupled nanoparticles induce tolerance in ‘humanised’ HLA-transgenic mice and inhibit diabetogenic CD8+ T cell responses in type 1 diabetes

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    2018-04-26 gds2009

    #D8+T#

    0

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    2018-02-03 ms5439512287675881

    #BET#

    0

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2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530040, encodeId=636115300405f, content=<a href='/topic/show?id=fd6f4340017' target=_blank style='color:#2F92EE;'>#多肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43400, encryptionId=fd6f4340017, topicName=多肽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb812012363, createdName=fusion, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-02-01 grace5700

    #T细胞应答#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1784049, encodeId=46e41e8404999, content=<a href='/topic/show?id=4b5c564252' target=_blank style='color:#2F92EE;'>#D8+T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5642, encryptionId=4b5c564252, topicName=D8+T)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Thu Apr 26 09:58:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760435, encodeId=f69a1e60435ab, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Feb 03 21:58:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058222, encodeId=df122058222d1, content=<a href='/topic/show?id=e8321802595' target=_blank style='color:#2F92EE;'>#T细胞应答#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18025, encryptionId=e8321802595, topicName=T细胞应答)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Thu Feb 01 03:58:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638302, encodeId=842a163830286, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Feb 01 23:58:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275221, encodeId=f3d42e522181, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Jan 04 04:57:36 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323379, encodeId=934313233e9d8, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471917, encodeId=ced614e1917fc, content=<a href='/topic/show?id=e97a93305ec' target=_blank style='color:#2F92EE;'>#转基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93305, encryptionId=e97a93305ec, topicName=转基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76227191338, createdName=旅苦化文_210, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502035, encodeId=9873150203543, content=<a href='/topic/show?id=14a6894190' target=_blank style='color:#2F92EE;'>#HLA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8941, encryptionId=14a6894190, topicName=HLA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e72c9501412, createdName=marongnuan, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516262, encodeId=8996151626271, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530040, encodeId=636115300405f, content=<a href='/topic/show?id=fd6f4340017' target=_blank style='color:#2F92EE;'>#多肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43400, encryptionId=fd6f4340017, topicName=多肽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb812012363, createdName=fusion, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-02-01 ms9608593228839890

    #DIA#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1784049, encodeId=46e41e8404999, content=<a href='/topic/show?id=4b5c564252' target=_blank style='color:#2F92EE;'>#D8+T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5642, encryptionId=4b5c564252, topicName=D8+T)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Thu Apr 26 09:58:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760435, encodeId=f69a1e60435ab, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Feb 03 21:58:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058222, encodeId=df122058222d1, content=<a href='/topic/show?id=e8321802595' target=_blank style='color:#2F92EE;'>#T细胞应答#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18025, encryptionId=e8321802595, topicName=T细胞应答)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Thu Feb 01 03:58:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638302, encodeId=842a163830286, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, 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encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471917, encodeId=ced614e1917fc, content=<a href='/topic/show?id=e97a93305ec' target=_blank style='color:#2F92EE;'>#转基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93305, encryptionId=e97a93305ec, topicName=转基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76227191338, createdName=旅苦化文_210, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502035, encodeId=9873150203543, content=<a href='/topic/show?id=14a6894190' target=_blank style='color:#2F92EE;'>#HLA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8941, encryptionId=14a6894190, topicName=HLA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e72c9501412, createdName=marongnuan, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516262, encodeId=8996151626271, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530040, encodeId=636115300405f, content=<a href='/topic/show?id=fd6f4340017' target=_blank style='color:#2F92EE;'>#多肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43400, encryptionId=fd6f4340017, topicName=多肽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb812012363, createdName=fusion, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-01-04 1e1c07bdm01(暂无匿称)

    好

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1784049, encodeId=46e41e8404999, content=<a href='/topic/show?id=4b5c564252' target=_blank style='color:#2F92EE;'>#D8+T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5642, encryptionId=4b5c564252, topicName=D8+T)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Thu Apr 26 09:58:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760435, encodeId=f69a1e60435ab, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, 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content=<a href='/topic/show?id=14a6894190' target=_blank style='color:#2F92EE;'>#HLA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8941, encryptionId=14a6894190, topicName=HLA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e72c9501412, createdName=marongnuan, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516262, encodeId=8996151626271, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530040, encodeId=636115300405f, content=<a href='/topic/show?id=fd6f4340017' target=_blank style='color:#2F92EE;'>#多肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43400, encryptionId=fd6f4340017, topicName=多肽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb812012363, createdName=fusion, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-01-02 ms3117646317107274

    #纳米颗粒#

    0

  7. 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encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Feb 01 23:58:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275221, encodeId=f3d42e522181, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Jan 04 04:57:36 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323379, encodeId=934313233e9d8, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471917, encodeId=ced614e1917fc, content=<a href='/topic/show?id=e97a93305ec' target=_blank style='color:#2F92EE;'>#转基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93305, encryptionId=e97a93305ec, topicName=转基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76227191338, createdName=旅苦化文_210, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502035, encodeId=9873150203543, content=<a href='/topic/show?id=14a6894190' target=_blank style='color:#2F92EE;'>#HLA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8941, encryptionId=14a6894190, topicName=HLA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e72c9501412, createdName=marongnuan, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516262, encodeId=8996151626271, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530040, encodeId=636115300405f, content=<a href='/topic/show?id=fd6f4340017' target=_blank style='color:#2F92EE;'>#多肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43400, encryptionId=fd6f4340017, topicName=多肽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb812012363, createdName=fusion, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-01-02 旅苦化文_210

    #转基因#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1784049, encodeId=46e41e8404999, content=<a href='/topic/show?id=4b5c564252' target=_blank style='color:#2F92EE;'>#D8+T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5642, encryptionId=4b5c564252, topicName=D8+T)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Thu Apr 26 09:58:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760435, encodeId=f69a1e60435ab, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, 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encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471917, encodeId=ced614e1917fc, content=<a href='/topic/show?id=e97a93305ec' target=_blank style='color:#2F92EE;'>#转基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93305, encryptionId=e97a93305ec, topicName=转基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76227191338, createdName=旅苦化文_210, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502035, encodeId=9873150203543, content=<a href='/topic/show?id=14a6894190' target=_blank style='color:#2F92EE;'>#HLA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8941, encryptionId=14a6894190, topicName=HLA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e72c9501412, createdName=marongnuan, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516262, encodeId=8996151626271, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530040, encodeId=636115300405f, content=<a href='/topic/show?id=fd6f4340017' target=_blank style='color:#2F92EE;'>#多肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43400, encryptionId=fd6f4340017, topicName=多肽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb812012363, createdName=fusion, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-01-02 marongnuan

    #HLA#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1784049, encodeId=46e41e8404999, content=<a href='/topic/show?id=4b5c564252' target=_blank style='color:#2F92EE;'>#D8+T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5642, encryptionId=4b5c564252, topicName=D8+T)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Thu Apr 26 09:58:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760435, encodeId=f69a1e60435ab, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, 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encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471917, encodeId=ced614e1917fc, content=<a href='/topic/show?id=e97a93305ec' target=_blank style='color:#2F92EE;'>#转基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93305, encryptionId=e97a93305ec, topicName=转基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76227191338, createdName=旅苦化文_210, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502035, encodeId=9873150203543, content=<a href='/topic/show?id=14a6894190' target=_blank style='color:#2F92EE;'>#HLA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8941, encryptionId=14a6894190, topicName=HLA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e72c9501412, createdName=marongnuan, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516262, encodeId=8996151626271, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530040, encodeId=636115300405f, content=<a href='/topic/show?id=fd6f4340017' target=_blank style='color:#2F92EE;'>#多肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43400, encryptionId=fd6f4340017, topicName=多肽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb812012363, createdName=fusion, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-01-02 41514490@qq.com

    #转基因小鼠#

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1784049, encodeId=46e41e8404999, content=<a href='/topic/show?id=4b5c564252' target=_blank style='color:#2F92EE;'>#D8+T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5642, encryptionId=4b5c564252, topicName=D8+T)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Thu Apr 26 09:58:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760435, encodeId=f69a1e60435ab, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, 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content=<a href='/topic/show?id=14a6894190' target=_blank style='color:#2F92EE;'>#HLA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8941, encryptionId=14a6894190, topicName=HLA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e72c9501412, createdName=marongnuan, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516262, encodeId=8996151626271, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530040, encodeId=636115300405f, content=<a href='/topic/show?id=fd6f4340017' target=_blank style='color:#2F92EE;'>#多肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43400, encryptionId=fd6f4340017, topicName=多肽)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb812012363, createdName=fusion, createdTime=Tue Jan 02 14:58:00 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-01-02 fusion

    #多肽#

    0

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近日，国际杂志 《Diabetologia》上在线发表一项关于终止妊娠和绝育的女性与幼年1型糖尿病发病的研究。这项研究的目的是探讨1型糖尿病与女性生殖健康指标之间的关系，重点是终止妊娠和绝育。 研究人员进行了一项注册研究队列研究，涉及2281名儿童期发病的1型糖尿病女性，年龄和出生地与无糖尿病的女性相匹配，每位糖尿病女性与两名对照参与者匹配。研究人员比较了25年间1型糖尿病女性和没有的女性终

Diabetologia：IL-12家族细胞因子在自身免疫性胰岛移植失败小鼠中的差异调节

近日，国际杂志 《Diabetologia》上在线发表一项关于IL-12家族细胞因子在自身免疫性胰岛移植失败小鼠中的差异调节的研究。根据不同的T细胞相关细胞因子缺陷动物模型和移植物类型提供的证据表明T辅助（Th）1和Th17细胞在移植排斥中的相对贡献是不确定的。 研究人员使用新型抗原呈递细胞特异性IL-12p35（也称为Il12a） - 敲除（KO），IL-23p19-敲低（KD）和IL-2

Diabetologia：血浆N-糖组复杂性增加与2型糖尿病的风险增高有关

研究发现2型糖尿病风险升高（急性炎症和急性炎症复制的人群）个体，在基线（FinRisk人口）收集的2型糖尿病的发病病例和升高的糖化血红蛋白个体（ORCADES和SABRE人群）全部呈现分枝增加，半乳糖基和血浆蛋白N-聚糖的唾液酸化，且这些变化具有相似的量值。

Diabetologia：妊娠期视网膜微血管及产后5年糖代谢异常的风险

视网膜微血管变化可能反映胰岛素抵抗。研究人员检查了基线和产后5年母亲队列中妊娠期间视网膜微血管变化与随后的糖代谢异常的风险之间的关系。

Diabetologia：联合基因组学和流行病学（PAGE）从人口结构精细定位研究血糖遗传学的跨性别特征

近日，国际杂志 《Diabetologia》上在线发表一项关于联合基因组学和流行病学（PAGE）从人口结构精细定位研究血糖遗传学的跨性别特征结果的研究。 非糖尿病个体空腹血糖和空腹胰岛素水平升高是糖代谢异常的标志，也是2型糖尿病的高风险因素。全基因组关联研究发现超过50个SNP与这些性状相关。这些基因座中的大部分都是在欧洲人群中发现的，并没有经过一项功能强大的多民族研究的测试。研究人员假设一