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J Antimicrob Chemother：重症肺炎患者给予低剂量哌拉西林他唑巴坦机能达到目标PK/PD？

2018-06-01 何娜 环球医学网

重症肺炎患者低剂量哌拉西林他唑巴坦机PK/PD
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发表于《J Antimicrob Chemother》上的一项研究，对重症患者和健康志愿者血清和肺部哌拉西林暴露进行了比较。

发表于《J Antimicrob Chemother》上的一项研究，对重症患者和健康志愿者血清和肺部哌拉西林暴露进行了比较。

背景：重症患者常见呼吸道重症感染，并与较高的发病率和死亡率相关。哌拉西林常用于治疗重症患者的肺部感染。保持肺部上皮细胞衬液（ELF）中充分的抗生素浓度对于肺部感染的成功治疗来说非常必要。

目的：旨在比较健康志愿者和重症患者的血清和ELF中，哌拉西林的药物代谢动力学/药效学。

方法：使用群体方法比较健康志愿者和重症患者的血清和ELF中的哌拉西林浓度。

结果：与健康志愿者相比，重症患者血清和ELF中哌拉西林中位暴露显着性高。重症患者血清哌拉西林暴露的IQR比健康志愿者高6倍。重症患者ELF中哌拉西林暴露的IQR比健康志愿者高4倍。健康志愿者肺部哌拉西林中位渗透比为0.31，重症患者为0.54。

结论：与健康志愿者相比，重症患者血清和ELF中哌拉西林浓度存在更大的变异，因此必须要在剂量方案的开发中予以考虑。药物研发期间，应该在重症患者和健康志愿者中研究抗菌药的肺部渗透性，以确保肺炎患者合理的剂量。

原始出处：
Felton TW, Ogungbenro K, Boselli E, et al.Comparison of piperacillin exposure in the lungs of critically ill patients and healthy volunteers.J Antimicrob Chemother. 2018. doi: 10.1093/jac/dkx541. [Epub ahead of print]

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    2019-01-17 ms7258648636991762

    #哌拉西林他唑巴坦机#

    0

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    2019-04-17 柳叶一刀

    #CRO#

    0

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    2018-09-25 xjy02

    #Micro#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2066511, encodeId=40b820665111f, content=<a href='/topic/show?id=49ee399020f' target=_blank style='color:#2F92EE;'>#哌拉西林他唑巴坦机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39902, encryptionId=49ee399020f, topicName=哌拉西林他唑巴坦机)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Thu Jan 17 17:31:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857655, encodeId=f680185e655c1, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Apr 17 17:31:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084406, encodeId=78f820844067f, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Sep 25 00:31:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789094, encodeId=2c4f1e890942e, content=<a href='/topic/show?id=57fe1431e93' target=_blank style='color:#2F92EE;'>#PK/PD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14317, encryptionId=57fe1431e93, topicName=PK/PD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sun Dec 09 17:31:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480499, encodeId=f91a14804992d, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579707, encodeId=94f115e97070c, content=<a href='/topic/show?id=d159959e438' target=_blank style='color:#2F92EE;'>#重症肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95974, encryptionId=d159959e438, topicName=重症肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7be916553908, createdName=1249883fm17暂无昵称, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320583, encodeId=7d83320583f5, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 01 16:38:16 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320577, encodeId=f5dd3205e759, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jun 01 16:11:43 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-12-09 lqvr

    #PK/PD#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2066511, encodeId=40b820665111f, content=<a href='/topic/show?id=49ee399020f' target=_blank style='color:#2F92EE;'>#哌拉西林他唑巴坦机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39902, encryptionId=49ee399020f, topicName=哌拉西林他唑巴坦机)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Thu Jan 17 17:31:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857655, encodeId=f680185e655c1, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Apr 17 17:31:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084406, encodeId=78f820844067f, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Sep 25 00:31:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789094, encodeId=2c4f1e890942e, content=<a href='/topic/show?id=57fe1431e93' target=_blank style='color:#2F92EE;'>#PK/PD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14317, encryptionId=57fe1431e93, topicName=PK/PD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sun Dec 09 17:31:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480499, encodeId=f91a14804992d, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579707, encodeId=94f115e97070c, content=<a href='/topic/show?id=d159959e438' target=_blank style='color:#2F92EE;'>#重症肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95974, encryptionId=d159959e438, topicName=重症肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7be916553908, createdName=1249883fm17暂无昵称, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320583, encodeId=7d83320583f5, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 01 16:38:16 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320577, encodeId=f5dd3205e759, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jun 01 16:11:43 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-03 ms1292405679162969

    #低剂量#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2066511, encodeId=40b820665111f, content=<a href='/topic/show?id=49ee399020f' target=_blank style='color:#2F92EE;'>#哌拉西林他唑巴坦机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39902, encryptionId=49ee399020f, topicName=哌拉西林他唑巴坦机)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Thu Jan 17 17:31:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857655, encodeId=f680185e655c1, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Apr 17 17:31:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084406, encodeId=78f820844067f, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Sep 25 00:31:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789094, encodeId=2c4f1e890942e, content=<a href='/topic/show?id=57fe1431e93' target=_blank style='color:#2F92EE;'>#PK/PD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14317, encryptionId=57fe1431e93, topicName=PK/PD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sun Dec 09 17:31:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480499, encodeId=f91a14804992d, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579707, encodeId=94f115e97070c, content=<a href='/topic/show?id=d159959e438' target=_blank style='color:#2F92EE;'>#重症肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95974, encryptionId=d159959e438, topicName=重症肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7be916553908, createdName=1249883fm17暂无昵称, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320583, encodeId=7d83320583f5, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 01 16:38:16 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320577, encodeId=f5dd3205e759, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jun 01 16:11:43 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-03 1249883fm17暂无昵称

    #重症肺炎#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2066511, encodeId=40b820665111f, content=<a href='/topic/show?id=49ee399020f' target=_blank style='color:#2F92EE;'>#哌拉西林他唑巴坦机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39902, encryptionId=49ee399020f, topicName=哌拉西林他唑巴坦机)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Thu Jan 17 17:31:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857655, encodeId=f680185e655c1, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Apr 17 17:31:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084406, encodeId=78f820844067f, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Sep 25 00:31:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789094, encodeId=2c4f1e890942e, content=<a href='/topic/show?id=57fe1431e93' target=_blank style='color:#2F92EE;'>#PK/PD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14317, encryptionId=57fe1431e93, topicName=PK/PD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sun Dec 09 17:31:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480499, encodeId=f91a14804992d, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579707, encodeId=94f115e97070c, content=<a href='/topic/show?id=d159959e438' target=_blank style='color:#2F92EE;'>#重症肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95974, encryptionId=d159959e438, topicName=重症肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7be916553908, createdName=1249883fm17暂无昵称, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320583, encodeId=7d83320583f5, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 01 16:38:16 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320577, encodeId=f5dd3205e759, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jun 01 16:11:43 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-01 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2066511, encodeId=40b820665111f, content=<a href='/topic/show?id=49ee399020f' target=_blank style='color:#2F92EE;'>#哌拉西林他唑巴坦机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39902, encryptionId=49ee399020f, topicName=哌拉西林他唑巴坦机)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Thu Jan 17 17:31:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857655, encodeId=f680185e655c1, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Apr 17 17:31:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084406, encodeId=78f820844067f, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Sep 25 00:31:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789094, encodeId=2c4f1e890942e, content=<a href='/topic/show?id=57fe1431e93' target=_blank style='color:#2F92EE;'>#PK/PD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14317, encryptionId=57fe1431e93, topicName=PK/PD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sun Dec 09 17:31:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480499, encodeId=f91a14804992d, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579707, encodeId=94f115e97070c, content=<a href='/topic/show?id=d159959e438' target=_blank style='color:#2F92EE;'>#重症肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95974, encryptionId=d159959e438, topicName=重症肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7be916553908, createdName=1249883fm17暂无昵称, createdTime=Sun Jun 03 06:31:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320583, encodeId=7d83320583f5, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 01 16:38:16 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320577, encodeId=f5dd3205e759, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jun 01 16:11:43 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-01 张新亮1853311252142e2fm

    好文献学习了

    0