Chest:慢性咳嗽的危险因素研究

2017-06-22 fengxiangxin MedSci原创

以往的报道还没有系统地描述过在一般人群中慢性咳嗽的危险因素。最近研究者使用哥本哈根普通人群研究的14669例个体的数据,分别在个体层面和社区层面上对慢性咳嗽危险因素进行了识别和分级。并将结果发表在医学知名期刊Chest上。

以往的报道还没有系统地描述过在一般人群中慢性咳嗽的危险因素。最近研究者使用哥本哈根普通人群研究的14669例个体的数据,分别在个体层面和社区层面上对慢性咳嗽危险因素进行了识别和分级。并将结果发表在医学知名期刊Chest上。

研究者采用Leicester 咳嗽问卷(LCQ)对慢性咳嗽的严重程度进行评估,并基于个体水平的年龄调整比值比(ORs)和社区水平的人群归因危险度(PARs)对慢性咳嗽危险因素的危险程度进行排列。

慢性咳嗽在一般人群中患病率为4%,在从未吸烟人群中为3%,在有吸烟经历人群中为4%,在目前吸烟人群中为8%。Leicester 咳嗽问卷(LCQ)在生理领域中位评分为5.8分(25-75百分位数:5.0-6.3),心理领域中位评分为5.6分(25-75百分位数:4.6-6.3),社会领域中位评分为6.3分(25-75百分位数:5.5-6.8)以及总中位评分为17.3分(25-75百分位数:15.4-18.9)。

在个体层面上,这些危险因素中,年龄调整后OR值最高的前三位在从未吸烟者中分别是支气管扩张(5分,95%置信区间:1.4-18),哮喘(2.6分,1.7-3.9)和胃食管反流病(2.3分,1.5-3.4);在从前有吸烟经历者中分别是支气管扩张(7.1分,2.6-20),哮喘(3.1分,2.2-4.4)和职业暴露于粉尘/烟雾(2.2分,1.5-3.2),以及在目前吸烟人群中为气流受限(1.9分,1.3-2.9)。

在社区层面上,排名最高的三个危险的因素在从不吸烟者中分别是女性(PAR:19%),哮喘(10%)和胃食管反流病(8%);在从前有吸烟经历人群中分别为腹型肥胖(20%),低收入(20%)和哮喘(13%),以及在目前吸烟人群中为气流受限(23%)。

所以此项研究得出结论:在个人层面和社区层面以及不同吸烟状况群体中慢性咳嗽的危险因素有所不同。制定预防和治疗慢性咳嗽的策略应结合相应的危险因素进行调整。

原始出处:

Colak, Y., B.G. Nordestgaard, L.C. Laursen, et al., Risk Factors for Chronic Cough Among 14 669 Individuals from the General Population. Chest,2017 Jun 15. pii: S0012-3692(17)31071-1. doi: 10.1016/j.chest.2017.05.038.

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    2018-02-01 Smile2680
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    2017-06-22 Y—xianghai

    学习了新知识

    0

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    2017-06-22 fengxiangxin301

    很好

    0

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    2017-06-22 fengxiangxin301

    慢性咳嗽炒鸡难受

    0

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慢性咳嗽是指以咳嗽为唯一或主要症状,持续8周以上且胸片未见明显异常者。在呼吸内科门诊中,慢性咳嗽占据很大比例。2009年我国咳嗽指南指出:慢性咳嗽的最常见病因包括上气道咳嗽综合征(UACS)、咳嗽变应性哮喘(CVA)、嗜酸性粒细胞性支气管炎(EB)、胃食管反流性咳嗽(GERC),这四个病因占呼吸内科门诊慢性咳嗽病因的70%-95%。

Chest:阿片类药物和某些非阿片类药物可有效治疗成人慢性咳嗽

了解不同疗法对不明原因咳嗽、或顽固性咳嗽的相对效果,有助于加深人们对这一独特群体中各疗法的效果及其潜在不良反应的认识。为此,来自美国北卡罗莱那州杜克大学医学中心医学部的William博士等人进行了一项研究,研究结果在线发表于2013年8月8日的CHEST杂志上。研究发现,阿片类药物和某些非阿片类/非麻醉性止咳药对成人慢性咳嗽的治疗有明确效果。【原文下载】 该研究是一项文献荟萃分析性研究。研究者对