BMJ:ZIKA病毒感染与新生儿结局

2018-11-01 zhangfan MedSci原创

研究认为在已知产妇ZIKA病毒感染的情况下,大约四分之一的胎儿存在先天感染,其中三分之一的胎儿在出生时会出现严重并发症或胎儿丢失

近日研究人员就寨卡病毒母婴传播率、胎儿/新生儿不良结局进行了研究。

研究在西法属圭亚那开展,300名怀孕任何阶段,经实验室证实有症状或无症状的寨卡病毒感染妇女参与,包含305名胎儿或新生儿。研究的主要终点为ZIKA病毒母婴传播率(羊水、胎儿和新生儿血液、尿液、脑脊液和胎盘);临床、生物学和放射学结果、先天性ZIKA综合征(CZS)、与CZS相关的严重并发症或胎儿丢失。同时考察了实验室确认的先天性ZIKA病毒感染与胎儿/新生儿不良结局之间的关系。

研究收集了26%(76/291)的胎儿/新生儿的母婴传播完整数据。在ZIKA病毒呈阳性的胎儿/新生儿中,45%(34/76)在出生时没有症状/并发症,20%(15/76)存在疑似CZS相关的中度症状,21%(16/76)的并发症与CZS相一致,14%(11/76)出现胎儿丢失。相比于阳性胎儿或新生儿,阴性新生儿严重并发症(5%)或胎儿丢失(0.5%)风险极低。寨卡病毒试验阳性与任何胎儿/新生儿不良结局之间的相关性显著 (RR=4.4)。先天性病毒感染导致47%的不良结果,以及61%的严重不良结果。

研究认为在已知产妇ZIKA病毒感染的情况下,大约四分之一的胎儿存在先天感染,其中三分之一的胎儿在出生时会出现严重并发症或胎儿丢失。

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    2019-02-20 gaoxiaoe
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    2018-11-04 吴教授

    学习了,学习了,学习了

    0

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    2018-11-01 龙胆草

    学习谢谢分享

    0

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