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Circulation：动脉粥样硬化中的重要环节！

2017-02-02 MedSci MedSci原创

动脉粥样硬化坏死吞噬
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坏死的中心一直是脆弱的动脉粥样硬化斑块的标志。尽管凋亡细胞在几乎所有的其他组织床中可以被迅速清除，但是在病变血管中它们的去除似乎显着受损。最新的证据表明，这种现象是由胞葬作用（Efferocytosis）缺陷引起的，一种凋亡组织被吞噬细胞（如巨噬细胞）识别并吞噬的过程。遗传和实验数据表明，胞葬作用受损发生在动脉粥样硬化造成的所谓的“吃我配体”失调中，它可以调控决经历程序性细胞死亡的细胞吞噬。以下是

坏死的中心一直是脆弱的动脉粥样硬化斑块的标志。尽管凋亡细胞在几乎所有的其他组织床中可以被迅速清除，但是在病变血管中它们的去除似乎显着受损。


最新的证据表明，这种现象是由胞葬作用（Efferocytosis）缺陷引起的，一种凋亡组织被吞噬细胞（如巨噬细胞）识别并吞噬的过程。

遗传和实验数据表明，胞葬作用受损发生在动脉粥样硬化造成的所谓的“吃我配体”失调中，它可以调控决经历程序性细胞死亡的细胞吞噬。

以下是最近数据的总结，其指示胞葬作用是损伤扩大的主要不受欢迎的驱动因素，但是也可能作为防止斑块进展的潜在靶点的可逆性缺陷。

原始出处：
Kojima Y, Weissman IL, Leeper NJ. The Role of Efferocytosis in Atherosclerosis. Circulation. 2017 Jan 31;135(5):476-489.

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    2017-04-08 fzwish20000

    #重要环节#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1814860, encodeId=9d22181486003, content=<a href='/topic/show?id=3a18960e024' target=_blank style='color:#2F92EE;'>#重要环节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96070, encryptionId=3a18960e024, topicName=重要环节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Sat Apr 08 11:54:00 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944432, encodeId=71c8194443229, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sun Mar 05 23:54:00 CST 2017, time=2017-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=174144, encodeId=95901e41448b, content=很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=475d1368230, createdName=liujianhua1955, createdTime=Sat Feb 04 12:54:24 CST 2017, time=2017-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=173911, encodeId=4bbd1e391174, content=学习。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Fri Feb 03 08:17:56 CST 2017, time=2017-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=173883, encodeId=d9cb1e3883bb, content=嗯，学习了新的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170129/IMG588DDC7F8AC3C1672.jpg, createdBy=e4971654967, createdName=Healer, createdTime=Fri Feb 03 05:54:35 CST 2017, time=2017-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=173878, encodeId=b6b31e3878cf, content=长见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Fri Feb 03 05:09:06 CST 2017, time=2017-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=173853, encodeId=739e1e38530c, content=稳定斑块，避免斑块脱落, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Feb 02 23:30:31 CST 2017, time=2017-02-02, status=1, ipAttribution=)]
    2017-03-05 huangshifeng

    #粥样硬化#

    0

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    2017-02-04 liujianhua1955

    很受益

    0

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    2017-02-03 jihuaijun1112

    学习。。。。。

    0

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    2017-02-03 Healer

    嗯，学习了新的内容

    0

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    2017-02-03 卡圣

    长见识了

    0

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    2017-02-02 有备才能无患

    稳定斑块，避免斑块脱落

    0

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