BMJ:母乳喂养降低子宫内膜异位症风险

2017-09-03 海北 MedSci原创

子宫内膜异位症是一种困扰10%美国妇女的慢性疾病。近日,来自哈佛陈曾熙公共卫生学院的研究人员探究了一生中母乳喂养情况,纯母乳喂养,产后闭经和女性子宫内膜异位症之间的关系。

子宫内膜异位症是一种困扰10%美国妇女的慢性疾病。近日,来自哈佛陈曾熙公共卫生学院的研究人员探究了一生中母乳喂养情况,纯母乳喂养,产后闭经和女性子宫内膜异位症之间的关系。

研究人员共招募了72,394名女性,这些女性报告有一次或多次怀孕至少持续6个月的经历。其中3296名女性经腹腔镜确诊为子宫内膜异位症。对于每次怀孕,女性都报导了总哺乳时间,纯母乳喂养时间和产后闭经情况。

研究人员发现,母乳喂养的总体时间以及纯母乳喂养时间和子宫内膜异位症的风险降低显著相关。在报告一生中母乳喂养不足一个月的女性中,每10万人中有453例子宫内膜异位症患者,而在一生中母乳喂养超过36个月的女性中,每10万人中有184例子宫内膜异位症患者。总体母乳喂养时间每增加三个月,女性子宫内膜异位症风险就会降低8%(风险比为0.92, 95%置信区间为0.90至0.94; 趋势为P <0.001)。每次怀孕都纯母乳喂养的时间每增加三个月,女性子宫内膜异位症风险就会降低14%(0.86,0.81~0.90; 趋势为P <0.001)。和从未母乳喂养的女性相比,母乳喂养总体时间超过36个月的女性子宫内膜异位症的发生率降低40%(0.60,0.50~0.72)。母乳喂养的保护性关联在过去五年内分娩过的女性中最强(P = 0.04)。母乳喂养或纯母乳喂养和子宫内膜异位症之间的关联部分受产后闭经的影响(占母乳喂养的百分比为34%(95%置信区间15%至59%),纯母乳喂养占57%(27%至82%))。

因此,在经历过一次或多次怀孕持续至少6个月的女性中,母乳喂养与子宫内膜异位症的风险成反比。该联系部分受产后闭经影响,表明母乳喂养可能通过闭经和其他机制影响子宫内膜异位症的风险。鉴于子宫内膜异位症是慢性和不治之症,应进一步调查作为减轻孕妇风险重要行为的母乳喂养。


原始出处:

Leslie V Farland et al. History of breast feeding and risk of incident endometriosis: prospective cohort studyBMJ, 2017; j3778 DOI: 10.1136/bmj.j3778


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    2018-08-11 gaoxiaoe
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    2017-09-04 villahu
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    2017-09-03 随梦飞扬

    每次怀孕都纯母乳喂养的时间每增加三个月.女性子宫内膜异位症风险就会降低14%

    0

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    2017-09-03 蔬菜

    学习了新知识.谢谢谢谢

    0

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    2017-09-03 明月清辉

    谢谢分享.学习了

    0

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    2017-09-03 Y—xianghai

    学习了新知识

    0

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