Tumour Biol:白淋比高,则乳腺癌患者5年生存率差

2015-10-28 phylis 译 MedSci原创

炎症和肿瘤免疫的微环境是许多癌症预后的关键因素。这篇研究旨在确定乳腺癌患者外周白淋比(NLR)的预后预测价值。研究者进行了一项回顾性研究,招募了2009年1月到2010年10期间,上海瑞金医院初诊为乳腺癌的487名患者。获得患者术前血液学检查参数,临床病理学数据及其生存状态。应用生存分析评估NLR的预后预测价值。随访时间的中位数为55个月,界值点为1.93。单变量分析中,与NLR较低的患者相比,N

炎症和肿瘤免疫的微环境是许多癌症预后的关键因素。这篇研究旨在确定乳腺癌患者外周白淋比(NLR)的预后预测价值。

研究者进行了一项回顾性研究,招募了2009年1月到2010年10期间,上海瑞金医院初诊为乳腺癌的487名患者。获得患者术前血液学检查参数,临床病理学数据及其生存状态。应用生存分析评估NLR的预后预测价值。

随访时间的中位数为55个月,界值点为1.93。单变量分析中,与NLR较低的患者相比,NLR较高(>1.93)的患者5年生存率(DSF)(77.9 vs 88.0 %)较低。NLR较低与NLR较高的患者整体生存率没有差异,五年整体生存率分别为90.8及91.7 %。三阴性的乳腺癌患者中,与低NLR值的患者相比,高NLR的患者与5年生存率较低有关(63.4 vs 84.9 %)。在多变量分析中,NLR是乳腺癌DFS的独立预后预测因子(HR = 1.867, 95%CI = 1.155-3.017)。

外周血NLR是乳腺癌患者,尤其是三阴性乳腺癌DFS的独立预测因子。需要进一步研究证实NLR对预后的预测效果。

原文出处:

Hong J, Mao Y, Chen X,et al. Elevated preoperative neutrophil-to-lymphocyte ratio predicts poor disease-free survival in Chinese women with breast cancer. Tumour Biol. 2015,Oct 21.


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    2016-04-14 sunylz
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