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2019年ACR：Equillium发表有关狼疮性肾炎中CD6-ALCAM途径的新见解

2019-11-07 Allan MedSci原创

CD6-ALCAM途径狼疮性肾炎Equillium
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Equillium是一家临床阶段的生物技术公司，旨在利用对免疫生物学的深刻理解来开发用于治疗严重自身免疫和炎性疾病的产品，近日宣布，将在2019年美国风湿病学会（ACR）年会上描述CD6-ALCAM途径在狼疮性肾炎中的重要作用。

Equillium是一家临床阶段的生物技术公司，旨在利用对免疫生物学的深刻理解来开发用于治疗严重自身免疫和炎性疾病的产品，近日宣布，将在2019年美国风湿病学会（ACR）年会上描述CD6-ALCAM途径在狼疮性肾炎中的重要作用。

狼疮性肾炎是指系统性红斑狼疮（SLE）合并双肾不同病理类型的免疫性损害，同时伴有明显肾脏损害临床表现的一种疾病。其发病与免疫复合物形成、免疫细胞和细胞因子等免疫异常有关。医学博士Chaim Putterman说：“狼疮性肾炎患者的肾脏中CD6-ALCAM信号显著增加，以及在狼疮性肾炎动物模型中CD6阻滞的相应功效，均支持使用itolizumab靶向狼疮性肾炎的治疗潜力”。


原始出处：

http://www.firstwordpharma.com/node/1679057#axzz64Xy4dOaT

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#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1675350, encodeId=253a16e535011, content=<a href='/topic/show?id=cb8a400091' target=_blank style='color:#2F92EE;'>#CAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4000, encryptionId=cb8a400091, topicName=CAM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ac27217804, createdName=whmdzju, createdTime=Sun Apr 12 18:02:00 CST 2020, time=2020-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779658, encodeId=8a511e796580e, content=<a href='/topic/show?id=f72a22e2b7' target=_blank style='color:#2F92EE;'>#ALCAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2272, encryptionId=f72a22e2b7, topicName=ALCAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Dec 11 18:02:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058320, encodeId=96532058320a9, content=<a href='/topic/show?id=e8254354e7' target=_blank style='color:#2F92EE;'>#CD6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4354, encryptionId=e8254354e7, topicName=CD6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Tue Nov 26 09:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387369, encodeId=5c21138e3694e, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400448, encodeId=6ade1400448bd, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532276, encodeId=95f615322e6cb, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631357, encodeId=daa7163135ec9, content=<a href='/topic/show?id=66e56905c7' target=_blank style='color:#2F92EE;'>#Equillium#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6905, encryptionId=66e56905c7, topicName=Equillium)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
    2020-04-12 whmdzju

    #CAM#

    0

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    2019-12-11 cqlidoudou

    #ALCAM#

    0

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    2019-11-26 amy0550

    #CD6#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1675350, encodeId=253a16e535011, content=<a href='/topic/show?id=cb8a400091' target=_blank style='color:#2F92EE;'>#CAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4000, encryptionId=cb8a400091, topicName=CAM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ac27217804, createdName=whmdzju, createdTime=Sun Apr 12 18:02:00 CST 2020, time=2020-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779658, encodeId=8a511e796580e, content=<a href='/topic/show?id=f72a22e2b7' target=_blank style='color:#2F92EE;'>#ALCAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2272, encryptionId=f72a22e2b7, topicName=ALCAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Dec 11 18:02:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058320, encodeId=96532058320a9, content=<a href='/topic/show?id=e8254354e7' target=_blank style='color:#2F92EE;'>#CD6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4354, encryptionId=e8254354e7, topicName=CD6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Tue Nov 26 09:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387369, encodeId=5c21138e3694e, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400448, encodeId=6ade1400448bd, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532276, encodeId=95f615322e6cb, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631357, encodeId=daa7163135ec9, content=<a href='/topic/show?id=66e56905c7' target=_blank style='color:#2F92EE;'>#Equillium#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6905, encryptionId=66e56905c7, topicName=Equillium)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
    2019-11-09 sunrural_42825357

    #狼疮#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1675350, encodeId=253a16e535011, content=<a href='/topic/show?id=cb8a400091' target=_blank style='color:#2F92EE;'>#CAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4000, encryptionId=cb8a400091, topicName=CAM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ac27217804, createdName=whmdzju, createdTime=Sun Apr 12 18:02:00 CST 2020, time=2020-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779658, encodeId=8a511e796580e, content=<a href='/topic/show?id=f72a22e2b7' target=_blank style='color:#2F92EE;'>#ALCAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2272, encryptionId=f72a22e2b7, topicName=ALCAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Dec 11 18:02:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058320, encodeId=96532058320a9, content=<a href='/topic/show?id=e8254354e7' target=_blank style='color:#2F92EE;'>#CD6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4354, encryptionId=e8254354e7, topicName=CD6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Tue Nov 26 09:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387369, encodeId=5c21138e3694e, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400448, encodeId=6ade1400448bd, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532276, encodeId=95f615322e6cb, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631357, encodeId=daa7163135ec9, content=<a href='/topic/show?id=66e56905c7' target=_blank style='color:#2F92EE;'>#Equillium#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6905, encryptionId=66e56905c7, topicName=Equillium)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
    2019-11-09 10518094zz

    #ACR#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1675350, encodeId=253a16e535011, content=<a href='/topic/show?id=cb8a400091' target=_blank style='color:#2F92EE;'>#CAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4000, encryptionId=cb8a400091, topicName=CAM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ac27217804, createdName=whmdzju, createdTime=Sun Apr 12 18:02:00 CST 2020, time=2020-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779658, encodeId=8a511e796580e, content=<a href='/topic/show?id=f72a22e2b7' target=_blank style='color:#2F92EE;'>#ALCAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2272, encryptionId=f72a22e2b7, topicName=ALCAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Dec 11 18:02:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058320, encodeId=96532058320a9, content=<a href='/topic/show?id=e8254354e7' target=_blank style='color:#2F92EE;'>#CD6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4354, encryptionId=e8254354e7, topicName=CD6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Tue Nov 26 09:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387369, encodeId=5c21138e3694e, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400448, encodeId=6ade1400448bd, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532276, encodeId=95f615322e6cb, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631357, encodeId=daa7163135ec9, content=<a href='/topic/show?id=66e56905c7' target=_blank style='color:#2F92EE;'>#Equillium#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6905, encryptionId=66e56905c7, topicName=Equillium)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
    2019-11-09 villahu

    #肾炎#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1675350, encodeId=253a16e535011, content=<a href='/topic/show?id=cb8a400091' target=_blank style='color:#2F92EE;'>#CAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4000, encryptionId=cb8a400091, topicName=CAM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ac27217804, createdName=whmdzju, createdTime=Sun Apr 12 18:02:00 CST 2020, time=2020-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779658, encodeId=8a511e796580e, content=<a href='/topic/show?id=f72a22e2b7' target=_blank style='color:#2F92EE;'>#ALCAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2272, encryptionId=f72a22e2b7, topicName=ALCAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Dec 11 18:02:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058320, encodeId=96532058320a9, content=<a href='/topic/show?id=e8254354e7' target=_blank style='color:#2F92EE;'>#CD6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4354, encryptionId=e8254354e7, topicName=CD6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Tue Nov 26 09:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387369, encodeId=5c21138e3694e, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400448, encodeId=6ade1400448bd, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532276, encodeId=95f615322e6cb, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631357, encodeId=daa7163135ec9, content=<a href='/topic/show?id=66e56905c7' target=_blank style='color:#2F92EE;'>#Equillium#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6905, encryptionId=66e56905c7, topicName=Equillium)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
    2019-11-09 zhaojie88

    #Equillium#

    0