Cell Metab：新研究为激活人类棕色脂肪改善脂代谢提供直接证据

2016-06-04 佚名生物谷

本文亮点：棕色脂肪组织（BAT）激活与脂质代谢加速有关冷冻能够诱导BAT中参与脂质代谢的基因表达 BAT线粒体的产热能力是白色脂肪组织（WAT）线粒体产热能力的45倍冷冻导致甘油三酯和VLDL水平出现延迟下降最近，国际学术期刊Cell Metabolism刊登了美国科学家的一项最新发现，在这篇文章中他们通过对冷冻刺激下人体的棕色脂肪组织和白色脂肪组织进行一系列研究发现人体棕色

本文亮点：

棕色脂肪组织（BAT）激活与脂质代谢加速有关

冷冻能够诱导BAT中参与脂质代谢的基因表达

BAT线粒体的产热能力是白色脂肪组织（WAT）线粒体产热能力的45倍

冷冻导致甘油三酯和VLDL水平出现延迟下降

最近，国际学术期刊Cell Metabolism刊登了美国科学家的一项最新发现，在这篇文章中他们通过对冷冻刺激下人体的棕色脂肪组织和白色脂肪组织进行一系列研究发现人体棕色脂肪组织可能在推动机体脂质代谢方面发挥重要作用。这项研究为利用人类棕色脂肪组织改善肥胖及糖脂代谢提供了新信息。

最近一些研究表明棕色脂肪组织在人类能量平衡和葡萄糖代谢过程中发挥一定作用。但是人类棕色脂肪组织在脂质代谢中的生理学重要意义仍然没有得到阐明。

在这项最新研究中，研究人员对16名超重/肥胖男性进行了研究，在研究过程中，参与者要处于长时间非战栗性冷刺激以及热中性环境下，研究人员通过稳定同位素示踪方法结合高胰岛素-正常血糖钳夹技术，以及BAT和WAT活检的方法进行了一系列研究。

研究结果表明BAT的含量与全身性脂质分解，甘油三酯-游离脂肪酸循环，游离脂肪酸氧化以及脂肪组织胰岛素敏感性等过程和指标的增强存在显著相关性。研究人员还对BAT和WAT这两种组织进行了功能分析，结果发现相比于WAT，BAT的产热能力更强，而分子学分析结果表明在冷冻环境下，BAT中参与脂质代谢的基因出现表达上调，并且这种现象仅存在于BAT中。

因此在BAT激活的状态下，脂肪动员和脂质氧化的过程也变得更快，这表明在人体内BAT可能在脂质代谢上调的过程中发挥一定作用。这项研究对于未来通过激活人体BAT改善肥胖以及糖脂代谢紊乱具有一定提示意义。.

原始出处

Maria Chondronikola, Elena Volpi, Elisabet Børsheim, Craig Porter, Manish K. Saraf, Palam Annamalai, Christina Yfanti, Tony Chao, Daniel Wong, Kosaku Shinoda, Sebastien M. Labbė, Nicholas M. Hurren, Fernardo Cesani, Shingo Kajimura, Labros S. SidossisBrown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans Cell Metab 2016

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2016-10-13 zhaozhouchifen

#Cell#

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2017-04-27 guojianrong

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2017-02-10 维他命

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2016-10-05 一闲

#MET#

33 0
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2016-06-06 huangdf

#脂代谢#

27 0
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2016-06-05 沉心多思

不错的文章，多学习

124 0
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2016-06-05 沉心多思

不错的文章，多学习

114 0

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