ANN RHEUM DIS：系统性红斑狼疮成人和儿童的生存率

2017-08-11 xiangting MedSci原创

经过一段时间的明显改善，自20世纪90年代中期以来SLE生存率达到平台期。

这项研究旨在确定1950年至今的系统性红斑狼疮（SLE）成人和儿童患者的生存率趋势。

研究人员进行了系统的文献检索以确定所有已发表的关于SLE患者生存的队列研究。使用Bayesian方法分别为成人和儿童患者以及来自高收入国家和低/中等收入国家的研究取得汇总的生存估计。汇集了同时期研究以获得生存趋势随时间的变化。还研究了主要死因的趋势。

共确定了125项成人研究和51项儿童研究。在成人中，高收入和低中收入国家的生存率从20世纪50年代到90年代中期均逐渐提高，其后出现生存率平台。2008-2016年，高收入国家成人的5年期，10年期和15年汇总生存率分别为0.95、0.89和0.82，低/中等收入国家分别为0.92、0.85和0.79。在儿童中，2008-2016年，高收入国家的5年期和10年期汇总生存率估计为0.99和0.97，而低中收入国家则分别为0.85和0.79。在成年人和高收入国家的儿童研究中，SLE造成的死亡比例随着时间的推移而下降。

经过一段时间的明显改善，自20世纪90年代中期以来SLE生存率达到平台期。在高收入国家成人和儿童的5年生存率均超过0.95。在低/中等收入国家，儿童的5年和10年生存率低于成人。

原始出处：

Maria G Tektonidou, et al. Survival in adults and children with systemic lupus erythematosus: a systematic review and Bayesian meta-analysis of studies from 1950 to 2016. ANN RHEUM DIS. 9 August 2017.

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#插入话题

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2017-12-19 cmj8wellington

#Dis#

32 0
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2018-06-29 qingrejiedu

#系统性#

29 0
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2017-08-13 guoyibin

#生存率#

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2017-08-13 sunrural_42825357

#狼疮#

32 0
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2017-08-13 zhouqu_8

#红斑#

27 0
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2017-08-11 明崖

好文章，学习了

61 0
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2017-08-11 天涯183

非常好的文章，学习了，很受益

55 0

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