Acta Biomater:3D打印水凝胶可用于快速神经修复

2019-05-20 不详 网络

神经导管为修复受损的周围神经提供了一种先进的治疗手段。目前,修复周围神经的导管效率不令人满意。在这里,我们展示了功能性纳米粒子增强神经导管,用于促进周围神经的再生。该导管由明胶-甲基丙烯酰(GelMA)水凝胶和载药聚(乙二醇) -聚(3-己内酯)(MPEG-PCL)纳米颗粒分散在水凝胶基质中组成,通过连续三维(3D)快速打印制备。结果显示,具有定制尺寸、形状和结构的3D打印水凝胶导管为轴突伸长提供

神经导管为修复受损的周围神经提供了一种先进的治疗手段。目前,修复周围神经的导管效率不令人满意。在这里,我们展示了功能性纳米粒子增强神经导管,用于促进周围神经的再生。

该导管由明胶-甲基丙烯酰(GelMA)水凝胶和载药聚(乙二醇) -聚(3-己内酯)(MPEG-PCL)纳米颗粒分散在水凝胶基质中组成,通过连续三维(3D)快速打印制备。结果显示,具有定制尺寸、形状和结构的3D打印水凝胶导管为轴突伸长提供物理微环境,纳米颗粒持续释放药物可促进神经再生。该药物为4-((5,10-二甲基-6-氧代-6,10-二氢-5H-嘧啶并[5,4-b]噻吩[3,2-e] [1,4]二氮杂-2-酮)氨基)苯磺酰胺是一种具有多种功能的Hippo途径抑制剂,包括改善施旺细胞的增殖和迁移以及上调神经营养因子基因。

总之,该研究所描述的功能性神经导管有效地诱导坐骨神经损伤的形态学,组织病理学和体内功能的恢复,显示出在周围神经修复中的潜在临床应用。

原始出处:

Tao J, Zhang J, et al.,  Rapid 3D printing of functional nanoparticle-enhanced conduits for effective nerve repair. Acta Biomater. 2019 May;90:49-59. doi: 10.1016/j.actbio.2019.03.047. Epub 2019 Mar 28.

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    2020-04-02 windight
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    2019-05-20 sunylz
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    2019-05-22 tastas
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    2019-05-22 lishizhe
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    2019-05-20 坚强007

    向挑战病魔的科研人员致敬!向挑战病魔的科研人员致敬!

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