Eur Heart J:肥胖手术对长期心血管结局的影响

2020-03-20 MedSci原创 MedSci原创

这项大型全国队列研究的结果支持了肥胖患者减肥手术与主要心血管事件和心力衰竭较低的长期风险之间的关系。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,该研究旨在评估减肥手术对肥胖患者心血管结局的长期影响。

研究人员在临床实践研究数据链中进行了嵌套队列研究,研究队列包括数据库中3701名接受过减肥手术的患者和3701名年龄、性别和体重指数匹配的对照组。该研究的主要终点为致死性或非致死性心肌梗死和致死性或非致死性缺血性卒中的复合终点。次要终点包括致死性或非致死性心肌梗死、致死性或非致死性缺血性卒中、心衰和死亡率。

中位随访时间为11.2年,接受过减肥手术的患者发生重大心血管不良事件的几率明显降低[风险比(HR)为0.410,95%置信区间(CI)为0.274-0.615;P<0.001)。这主要是由于心肌梗死的减少(HR为0.412, 95%CI为0.280-0.606;P<0.001),而非急性缺血性脑卒中(HR为0.536,95%CI为0.164-1.748;P=0.301)。新诊断的心力衰竭(HR为0.403,95%CI为0.181-0.897;P=0.026)和死亡率(HR为0.254, 95%CI为0.183-0.353;P<0.001)也观察到有所降低。

由此可见,这项大型全国队列研究的结果支持了肥胖患者减肥手术与主要心血管事件和心力衰竭较低的长期风险之间的关系。

原始出处:

Osama Moussa,et al.Effect of bariatric surgery on long-term cardiovascular outcomes: a nationwide nested cohort study.Eur Heart J.2020.https://doi.org/10.1093/eurheartj/ehaa069

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    2020-03-22 zhaojie88
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    2020-03-22 slcumt