Sci Rep:miR-143和miR-506联合多重活动抑制肺癌细胞周期和体外血管生成

2018-07-13 xiangting MedSci原创

结合RNA测序数据的通路分析,这项研究结果确定了联合miR转染作为肺癌治疗的可行策略,值得进一步研究。

肺癌(LC)是癌症相关死亡的首要病因。CDK1、4和6作为细胞周期的关键调节因子,其下调与LC细胞增殖降低相关。强制表达miRNAs(miRs)是一种很有前景的调节基因的方法。这篇文章研究了分别靶向CDK1、4/6基因的miR-143和miR-506联合治疗。

研究人员通过qPCR和蛋白质印迹分析了CDK基因的差异表达,并评估了联合治疗后细胞周期分布的变化。使用抗体微阵列分析评估蛋白质表达,主要是细胞周期通路,并进行RNA测序以进行通路分析。

联合miR治疗显著下调CDK1、4和6的表达,并诱导细胞周期群的转化,表明存在G1和G2细胞周期阻滞。两种miRs诱导产生强烈的细胞毒性,具有潜在协同作用,伴Caspase 3/7显著活化。在一个体外血管生成模型中确定了对管形成的强抑制作用,存在或不存在VEGF。

结合RNA测序数据的通路分析,这项研究结果确定了联合miR转染作为肺癌治疗的可行策略,值得进一步研究。

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    2018-09-01 smallant2002
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    2018-07-15 yxch36
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1930633, encodeId=2976193063302, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sat Sep 01 13:49:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079869, encodeId=083f20e986923, content=<a href='/topic/show?id=23f71182eb8' target=_blank style='color:#2F92EE;'>#miR-143#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11827, encryptionId=23f71182eb8, topicName=miR-143)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Oct 29 09:49:00 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069810, encodeId=5ac1206981010, content=<a href='/topic/show?id=904282239db' target=_blank style='color:#2F92EE;'>#肺癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82239, encryptionId=904282239db, topicName=肺癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Jan 01 06:49:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252519, encodeId=0b8c1252519ba, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Jul 15 06:49:00 CST 2018, time=2018-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287513, encodeId=1f5a128e513b9, content=<a href='/topic/show?id=1c48e783278' target=_blank style='color:#2F92EE;'>#细胞周期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77832, encryptionId=1c48e783278, topicName=细胞周期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Sun Jul 15 06:49:00 CST 2018, time=2018-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331609, encodeId=3df13316090a, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Jul 14 22:35:01 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331320, encodeId=9a87331320ec, content=学习了!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Jul 13 16:21:27 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331319, encodeId=1ebf3313195e, content=学习了!!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Jul 13 16:20:17 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-14 三生有幸9135

    学习一下

    0

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    2018-07-13 zb1235672

    学习了!!!!

    0

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    2018-07-13 zb1235672

    学习了!!!!!!

    0

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2018年6月,法国、英国、澳大利亚等国学者在《Ann Oncol》发表了一项在肺癌队列联盟(LC3)中进行的20项前瞻性研究的分析,考察了维生素D的循环浓度与肺癌风险之间的相关性

除了筛查,肺癌肿瘤标志物还有什么用处?

肺癌已经成为我国每年患病人数和死亡人数最多的肿瘤,关于肺癌的早期筛查和诊断起来越受到人们的关注。肿瘤标志物是1978年Herberman在美国国立癌症研究院召开的人类免疫及肿瘤免疫诊断会上提出的,1979年在英国第七届肿瘤发生生物学和医学会议上作为专用术语被大家公认。三十余年来,肿瘤标志物的研究逐渐形成了一门独立的学科分支。

Oncol Rep:过氧化氢可通过诱导细胞死亡和G1期阻滞来抑制肺癌细胞的生长

过氧化氢(H2O2)经常用于培养细胞以诱导氧化应激。本研究调查了外源性H2O2对Calu-6和A549肺癌细胞的作用。MTT测定显示,H2O2抑制Calu-6和A549细胞的生长,24小时IC50值分别为~50和100μM。用H2O2处理的细胞表现出细胞在G1期停滞。H2O2呈剂量依赖性地增加了这些细胞的死亡(台盼蓝阳性)和膜联蛋白V-FITC染色细胞的数量,伴随着Bcl-2和前半胱天冬酶-3水平

CLIN CANCER RES:EGFR突变肺癌中与EGFR酶抑制剂耐药有关的基因突变

CLIN CANCER RES近期发表了一篇文章,研究与EGFR酶抑制剂治疗效果有关的分子因素,寻找耐药机制。作者使用靶向二代测序技术分析了EGFR突变肿瘤治疗前与接受EGFR TKI治疗后进展的肿瘤分子情况。

肺癌为何会出现水泡样皮疹?

患者男性,32岁,因“发热、咳嗽伴皮疹3个月余”入院。