PNAS:新发现!抗癌药物或有助于治疗HPV感染

2018-12-04 周悦 生物探索

抗癌药物vorinostat、belinostat和panobinostat或可以被用于治疗由人乳头瘤病毒(HPV)引起的感染。

抗癌药物vorinostat、belinostat和panobinostat或可以被用于治疗由人乳头瘤病毒(HPV)引起的感染

近日,阿拉巴马大学伯明翰分校(University of Alabama at Birmingham)的研究人员发现,抗癌药物vorinostat、belinostat和panobinostat或可以被用于治疗由人乳头瘤病毒(HPV)引起的感染


图片来源: public domain

很多人都知道,HPV是导致宫颈癌的罪魁祸首。其实,目前发现的HPV也有不同的型别,带来的健康风险也有所不同。业界也有针对HPV感染的高效疫苗,比如说近日默沙东被批准的HPV疫苗Gardasil 9(加卫苗,9价),覆盖了9种HPV类型,可预防宫颈癌、外阴癌、阴道癌和肛门癌以及生殖器疣。

但是,HPV疫苗需要在性生活之前注射,因为它对现有的HPV感染没有治疗效果。根据世界卫生组织的数据,2012年世界范围内HPV感染导致约266,000例宫颈癌死亡。

“当下,迫切需要安全、有效和廉价的治疗药物。”论文的主要作者UAB生物化学和分子遗传学系N. Sanjib Banerjee博士如是说。

但HPVs不能在常规细胞培养中繁殖,这也阻碍了对其致病作用的研究。

UAB生物化学和分子遗传学系Louise Chow博士和Thomas Broker博士的实验室几十年来一直在致力于研究HPV和宿主的相互作用。他们发现HPV的产生依赖于上皮细胞分化成全层鳞状上皮细胞。此外,HPV在这些分化细胞中重新激活宿主DNA复制,使复制蛋白和底物能够支持病毒DNA的扩增。

Banerjee和同事们假设,组蛋白去乙酰化酶(HDACs)抑制剂会抑制HPV DNA扩增,因为它们已知的破坏染色体DNA复制的机制。

2009年,Chow和Broker实验室曾开发一种潜在的抗HPV(针对HPV-18)药物临床前研究的理想模型。如今,他们在这模型基础上发现,如他们所料,抗癌药vorinostat能有效抑制HPV-18 DNA扩增和病毒产生。

重要的是,vorinostat还诱导了一部分分化细胞中被称为凋亡的程序性细胞死亡。当染色体DNA复制被打断时,细胞死亡可能是由于DNA断裂造成的。另外两种HDAC抑制剂belinostat和panobinostat也获得了类似的结果。

Banerjee 表示,“在这些详细研究的基础上,我们认为HDAC抑制剂是治疗良性HPV感染的有前途的化合物。”

原始出处:N. Sanjib Banerjee, Dianne W. Moore, Thomas R. Broker, et al. Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification. PNAS. November 20, 2018

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1856246, encodeId=e9b718562460f, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Wed Dec 12 04:31:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921237, encodeId=9831192123ee4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Mar 08 17:31:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308262, encodeId=03a6130826292, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314829, encodeId=c0e0131482906, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483043, encodeId=4ae114830436a, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354522, encodeId=e5c9354522c3, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Dec 05 14:32:19 CST 2018, time=2018-12-05, status=1, ipAttribution=)]
    2018-12-12 drwjr
  2. [GetPortalCommentsPageByObjectIdResponse(id=1856246, encodeId=e9b718562460f, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Wed Dec 12 04:31:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921237, encodeId=9831192123ee4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Mar 08 17:31:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308262, encodeId=03a6130826292, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314829, encodeId=c0e0131482906, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483043, encodeId=4ae114830436a, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354522, encodeId=e5c9354522c3, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Dec 05 14:32:19 CST 2018, time=2018-12-05, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1856246, encodeId=e9b718562460f, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Wed Dec 12 04:31:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921237, encodeId=9831192123ee4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Mar 08 17:31:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308262, encodeId=03a6130826292, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314829, encodeId=c0e0131482906, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483043, encodeId=4ae114830436a, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354522, encodeId=e5c9354522c3, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Dec 05 14:32:19 CST 2018, time=2018-12-05, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1856246, encodeId=e9b718562460f, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Wed Dec 12 04:31:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921237, encodeId=9831192123ee4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Mar 08 17:31:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308262, encodeId=03a6130826292, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314829, encodeId=c0e0131482906, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483043, encodeId=4ae114830436a, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354522, encodeId=e5c9354522c3, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Dec 05 14:32:19 CST 2018, time=2018-12-05, status=1, ipAttribution=)]
    2018-12-05 sunylz
  5. [GetPortalCommentsPageByObjectIdResponse(id=1856246, encodeId=e9b718562460f, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Wed Dec 12 04:31:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921237, encodeId=9831192123ee4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Mar 08 17:31:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308262, encodeId=03a6130826292, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314829, encodeId=c0e0131482906, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483043, encodeId=4ae114830436a, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354522, encodeId=e5c9354522c3, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Dec 05 14:32:19 CST 2018, time=2018-12-05, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1856246, encodeId=e9b718562460f, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Wed Dec 12 04:31:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921237, encodeId=9831192123ee4, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Fri Mar 08 17:31:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308262, encodeId=03a6130826292, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314829, encodeId=c0e0131482906, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483043, encodeId=4ae114830436a, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Wed Dec 05 17:31:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354522, encodeId=e5c9354522c3, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Dec 05 14:32:19 CST 2018, time=2018-12-05, status=1, ipAttribution=)]
    2018-12-05 kafei

    学习了谢谢

    0

相关资讯

靶向RNA的抗癌药物!

“在现代制药纪元里,RNA是‘非主流’的药物靶标。事实上,我们发现一些已知药物的作用方式恰恰是与RNA结合,”Scripps研究所教授、化学家Matthew D. Disney博士说。“我们发现了广泛的RNA结合类药物。有理由相信,以RNA作为靶点亦是药物研发的一个可行出路。”

从《我不是药神》上映 看出国家释放的重要信号

《我不是药神》火了!电影还未正式上映便收获诸多好评。医疗圈人士以及与慢粒白血病相关的人对这部电影更为期待,因为他们更清楚癌症给一个家庭带来的痛苦以及政策变化中的酸甜苦辣。

国庆前北京14种抗癌药物降价到位,平均降幅4.7%

按照国务院对抗癌药专项采购的决策部署,在9月1日8种抗癌药调整采购价格和医保支付标准的基础上,第二批调价的6个品种也完成了采购价格和医保支付标准的调整,9月29日起,患者就可买到第二批降价后的药品。第二批调价的6种抗癌药,包括多吉美、易瑞沙、芙仕得、美罗华、安维汀、万珂等,平均降幅4.9%。如用于多发性骨髓瘤患者治疗用的万珂,从原来每支6116元下降至5639.5元,按照临床有效患者的治疗方案测算

抗癌药物治疗结核病

结核(Tuberculosis,简称TB)是常见并可致命的一种传染病,由分枝杆菌又称结核杆菌导致。结核通常感染并破坏肺以及淋巴系统,但其它器官如脑、中枢神经系统、循环系统、泌尿系统、骨骼、关节、甚至皮肤亦可受感染。近期,研究发现,实验性癌症化疗药物可能有助于根除结核病(TB)

Cell Rep:抗癌药物疗效增涨100%!只需阻止细胞的这种结构!

药物是很多疾病治疗的“基石”,尤其对癌症而言,而越来越普遍的耐药现象已成为癌症治疗的“绊脚石”。可喜的是,近日,科学家已经发现了一种使癌症对药物治疗敏感的全新方法, 即通过靶向细胞上的类天线结构。伦敦癌症研究所的研究小组发现,耐癌细胞比那些因治疗而死亡的细胞具有更多更长的触角。阻断触角生长的细胞可再次激活一系列已停止工作的癌症治疗。

专家解读:提升抗癌药物供应保障能力 创新与仿制缺一不可

我国每年新发癌症病例超350万,死亡病例超200万……据国家癌症中心统计数据显示,癌症已成为我国严重危害健康的重大公共卫生问题之一。日前,国家卫健委有关负责人在接受人民健康采访时表示,我国正采取多项措施,提高抗癌药供应保障能力,努力满足患者用药需求。