Eur Respir J:REM相关睡眠呼吸暂停的患病率和临床意义

2018-08-17 xing.T MedSci原创

由此可见,REM-SDB在中老年人样本中非常普遍,并且与代谢综合征和糖尿病独立相关。这些结果表明REM-AHI的增加可能与临床疾病相关。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,该研究旨在明确普通人群中快速眼动(REM)相关睡眠呼吸紊乱(REM-SDB)的患病率,并探究REM-SDB与高血压代谢综合征糖尿病和抑郁症之间的关系。

该研究分析了来自基于人群的HypnoLaus睡眠队列(48.3%为男性,57±11岁)个体的家庭多导睡眠图(PSG)记录(n=2074)。在REM和非REM睡眠期间研究人员测量了受试者的呼吸暂停-呼吸不足指数(分别为REM-AHI和NREM-AHI)。研究人员采用回归模型探讨了整个队列和NREM-AHI<10事件·h-1和总AHI<10事件·h-1的亚组中REM-SDB与高血压糖尿病代谢综合征和抑郁症之间的关联。

在整个队列中,REM-AHI≥20事件·h-1的患病率为40.8%。在整个队列和NREM-AHI以及AHI亚组中均发现REM-AHI增加与代谢综合征之间的关联(趋势P=0.014,分别<0.0001和0.015)。在整个队列和NREM-AHI<10事件·h-1(比值比(OR)3.12(95%CI为1.35-7.20))和AHI<10事件·h-1(OR为2.92(95%CI为1.12-7.63))的亚组中,REM-AHI≥20事件·h-1与糖尿病之间也存在关联。收缩压和舒张压与REM-AHI≥20事件·h-1呈正相关。

由此可见,REM-SDB在中老年人样本中非常普遍,并且与代谢综合征和糖尿病独立相关。这些结果表明REM-AHI的增加可能与临床疾病相关。

原始出处:

Patricia Acosta-Castro,et al. REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort. Eur Respir J. 2018. http://erj.ersjournals.com/content/52/2/1702484

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    2019-04-09 tongyongming
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