Int J Cardiol:D-二聚体阴性对急性主动脉夹层早期评估的影响!

2018-02-02 xing.T MedSci原创

由此可见,该研究发现高血小板计数和低扩张分数是导致D-二聚体阴性结果的独立因素。即使夹层长度很短,对于一些D-二聚体阴性的病人,急诊手术也是必要的。医生应该认识到血浆D-二聚体阴性结果的患者不能排除致命性AAD的情况。

二聚体具有很高的灵敏度,但对急性主动脉夹层(AAD)诊断的特异性较低。已有报道表明D-二聚体阴性患者的夹层长度较短。然而,D-二聚体阴性患者预后是否良好尚不清楚。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,该研究旨在探讨D-二聚体阴性结果对AAD诊断临床意义。

该研究纳入了在2009年4月和2015年3月之间入住研究者所在医疗机构的126例AAD患者(男性71例,女性55例;平均年龄为69±11岁)。就诊时采用血标本进行D-二聚体测定,并评估患者临床特征和结局。

分别有9例(7.1%)和117例(92.9%)患者D-二聚体表现为阴性和阳性。阴性组扩张评分明显低于阳性组,而血小板计数则高于阳性组。多因素分析表明,血小板计数(比值比为1.31(1.09-1.58),P=0.003)和扩展评分(比值比为0.56(0.33-0.96),P=0.03)是阴性结果显著相关。值得注意的是,阴性组中有44%的患者为A型夹层,33%的患者因心脏压塞而接受紧急手术。

由此可见,该研究发现高血小板计数和低扩张分数是导致D-二聚体阴性结果的独立因素。即使夹层长度很短,对于一些D-二聚体阴性的病人,急诊手术也是必要的。医生应该认识到血浆D-二聚体阴性结果的患者不能排除致命性AAD的情况。

原始出处:

Kenichi Nitta,et al. Impact of a negative D-dimer result on the initial assessment of acute aortic dissection.International Journal of Cardiology.2017. https://doi.org/10.1016/j.ijcard.2018.01.104

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    2018-09-29 hxj0117
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    2018-02-03 大爰

    学习并分享!!

    0

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    2018-02-02 120e71dcm28暂无昵称

    学习了.

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