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CLIN CANCER RES：抗GD2单抗联合化疗以及NK细胞治疗儿童复发或难治性神经母细胞瘤

2017-11-06 MedSci MedSci原创

神经母细胞瘤抗GD2单抗化疗NK细胞
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抗GD2单抗，通过抗体依赖细胞介导的细胞毒性发挥抗肿瘤作用，可能会增强化疗疗效。CLIN CANCER RES近期发表了一篇文章，研究固定剂量的抗GD2单抗（hu14.18K322A）联合化疗、细胞因子以及NK细胞的疗效。

抗GD2单抗，通过抗体依赖细胞介导的细胞毒性发挥抗肿瘤作用，可能会增强化疗疗效。CLIN CANCER RES近期发表了一篇文章，研究固定剂量的抗GD2单抗（hu14.18K322A）联合化疗、细胞因子以及NK细胞的疗效。

复发或难治性神经母细胞瘤的患者接受最多6个疗程的hu14.18K322A（40 mg/m2/dose，第2-5天）、GM-CSF、IL2联合化疗（环磷酰胺/托泊替康，1、2周期），（伊立替康/替莫唑胺，3、4周期），（异环磷酰胺/卡铂/依托泊苷，5、6周期）。在2、4、6周期输入NK细胞。收集hu14.18K322A血清药代动力学、可溶IL受体α（sIL2Rα）水平以及人抗人抗体（HAHA）数据。研究最终纳入13例接受过治疗的患者（9例接受过抗GD2治疗）。1例患者出现无法耐受的毒性（4级血小板减少超过45天）。4例患者由于不良反应中断治疗（hu14.18K322A 过敏反应，病毒感染，手术死亡，再发恶性肿瘤）。常见的毒性反应包括3/4级骨髓抑制和1/2级疼痛。11例患者接受29次NK细胞治疗。反应率为61.5%（4例完全反应，1例良好的部分反应，3例部分反应），5例患者病情稳定。疾病平均进展时间为274天。10患者存活超过一年。化疗或HAHA不会影响hu14.18K322A的药代动力学。所有患者sIL2Rα水平均增加，表明免疫系统激活。

文章最后认为，化疗联合hu14.18K322A，细胞因子和NK细胞治疗复发或难治性神经母细胞瘤是可行的且临床反应明显。这一疗法的进一步临床试验目标应为复发或新发的神经母细胞瘤患者。

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    2018-10-21 huperzia

    #母细胞瘤#

    0

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    2017-11-08 oliver170

    #联合化疗#

    0

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    2017-11-08 spoonycyy

    #细胞瘤#

    0

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    2017-11-08 freve

    #难治性#

    0

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    2017-11-06 天涯183

    非常好的文章.学习了

    0

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Nanoscale：装载香料的“纳米炮弹”能杀灭癌细胞

科学家提出了一种潜在的新方法来治疗神经母细胞瘤。这是儿童最常见的颅外肿瘤，是婴儿最常见的癌症。研究人员使用装载姜黄成分的纳米颗粒来杀灭癌细胞。该研究已于近日发表在《Nanoscale》上。