Semin Arthritis Rheu:系统性红斑狼疮患者的足部及脚踝特征

2018-08-07 xiangting MedSci原创

SLE患者有多种足部及脚踝表现。已发表的研究主要强调了外周动脉疾病、周围神经病变、肌肉骨骼畸形、皮肤和指甲病变以及患者报告的足部疼痛和残疾的影响。

这项研究旨在确定系统性红斑狼疮(SLE)患者足部及脚踝的特征。

检索Medline、CINAHL、Sports-Discus、Scopus和Cochrane图书馆数据库2018年1月之前收录的研究。纳入报告以下方面足部及脚踝相关结局的研究:血管、神经、肌肉骨骼、皮肤(皮肤和指甲)或疼痛/功能。使用质量指数工具评估方法学质量。在适当的情况下,对病例对照研究进行优势比和平均差异meta分析;对评估SLE特征的研究进行汇总平均患病率meta分析。 

纳入了49项研究,平均(范围)质量得分为75%(38-100%)。23项研究评估了血管特征,其次是肌肉骨骼(n=16)、神经系统(n?=11)、皮肤(n=5)和疼痛/功能(n= 4)。SLE患者的足部及脚踝特征包括血管供应受损、神经功能异常、肌肉骨骼病变、皮肤和指甲病变,疼痛和功能障碍。meta分析纳入了24项研究。与对照相比,SLE的异常汇总踝臂指数为3.08。SLE与对照的臂踝脉搏波速度的汇总平均差异显著(161.39cm/s,p= 0.004)。间歇性跛行的合并患病率为0.54,雷诺现象0.50,冻疮0.28,坏疽0.00,拇外翻0.30,甲真菌病0.15,足部疼痛史0.76,当前足部疼痛0.36。

SLE患者有多种足部及脚踝表现。已发表的研究主要强调了外周动脉疾病、周围神经病变、肌肉骨骼畸形、皮肤和指甲病变以及患者报告的足部疼痛和残疾的影响。

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    2018-08-09 zhaojie88
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    2018-08-09 zhouqu_8

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