Sci Rep:雄激素阻断治疗期间优先局部治疗和前列腺特异性抗原动力学对去势难治性前列腺癌生存的影响研究

2019-08-31 AlexYang MedSci原创

在去势难治性前列腺癌(CRPC)中,前列腺特异性抗原(PSA)动力学能够预测生存;然而,优先治疗对上述预测关系的影响仍旧不清楚。最近,有研究人员根据到PSA最低点时间和CRPC进展时间对CRPC患者进行了分层,从而来调查它们对前列腺癌特异性生存(PCSS)的预后意义以及是否在不考虑优先局部治疗的情况下,PSA动力学能够作为预测因子。他们的多中心回顾性研究包括了295名诊断为CRPC的患者,时间为2

在去势难治性前列腺癌(CRPC)中,前列腺特异性抗原(PSA)动力学能够预测生存;然而,优先治疗对上述预测关系的影响仍旧不清楚。

最近,有研究人员根据到PSA最低点时间和CRPC进展时间对CRPC患者进行了分层,从而来调查它们对前列腺癌特异性生存(PCSS)的预后意义以及是否在不考虑优先局部治疗的情况下,PSA动力学能够作为预测因子。他们的多中心回顾性研究包括了295名诊断为CRPC的患者,时间为2009年9月到2017年11月。在雄激素阻断治疗(ADT)期间,研究人员调查了PSA动力学相关参数,包括了PSA下降百分比、PSA最低水平、到PSA最低点时间和CRPC进展时间。另外,研究人员还根据先前局部治疗历史情况进行了亚群分析。研究发现,那些没有接受优先局部治疗且到PSA最低点时间不小于6个月和CPRC进展时间小于12个月的患者,表现出了比到PSA最低点时间小于6个月(23.3% vs. 45.3%; p=0.031)和CPRC进展时间不小于12个月(20.0% vs. 47.8%; p=0.001)的患者更低的PCSS。而在那些接受局部治疗的患者中,PSA动力学参数对PCSS并不产生影响。

最后,研究人员指出,他们的结果表明了到PSA最低点时间和CRPC进展时间是那些没有接受局部治疗的CRPC患者PCSS的预测因子。

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  5. 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  6. 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=1385165, encodeId=c09a1385165bd, content=<a href='/topic/show?id=fd1798e0222' target=_blank style='color:#2F92EE;'>#雄激素阻断治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98702, encryptionId=fd1798e0222, topicName=雄激素阻断治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03e7496, createdName=楚钟, createdTime=Mon Sep 02 03:36:00 CST 2019, time=2019-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405927, encodeId=6d22140592e3a, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Sep 02 03:36:00 CST 2019, time=2019-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425825, encodeId=0fa21425825e0, content=<a href='/topic/show?id=a1e44e62210' target=_blank style='color:#2F92EE;'>#局部治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47622, encryptionId=a1e44e62210, topicName=局部治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c1d3994789, createdName=venlin, createdTime=Mon Sep 02 03:36:00 CST 2019, time=2019-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528598, encodeId=8c0f152859844, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Mon Sep 02 03:36:00 CST 2019, time=2019-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623343, encodeId=088816233433e, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Mon Sep 02 03:36:00 CST 2019, time=2019-09-02, status=1, ipAttribution=)]
    2019-09-02 chg122
  8. [GetPortalCommentsPageByObjectIdResponse(id=1641282, encodeId=5ef216412824d, content=<a href='/topic/show?id=469998e01fb' target=_blank style='color:#2F92EE;'>#雄激素阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98701, encryptionId=469998e01fb, topicName=雄激素阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62c22776697, createdName=ms5106640509429053, createdTime=Fri May 29 13:36:00 CST 2020, time=2020-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1899322, encodeId=0ef8189932228, content=<a href='/topic/show?id=6f746e94170' target=_blank style='color:#2F92EE;'>#特异性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67941, encryptionId=6f746e94170, topicName=特异性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc7a157, createdName=jinweidong, createdTime=Tue Mar 17 17:36:00 CST 2020, time=2020-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957843, encodeId=17b5195e843a7, content=<a href='/topic/show?id=41cb6e95555' target=_blank style='color:#2F92EE;'>#特异性抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67955, encryptionId=41cb6e95555, topicName=特异性抗原)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Wed Apr 22 23:36:00 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710197, encodeId=c0f91e101974f, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, 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  9. 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encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Mon Sep 02 03:36:00 CST 2019, time=2019-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623343, encodeId=088816233433e, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Mon Sep 02 03:36:00 CST 2019, time=2019-09-02, status=1, ipAttribution=)]
    2019-09-02 freve
  10. 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