JAHA:白天过度嗜睡可独立预测心肌梗死后增加的心血管风险!

2018-01-20 xing.T MedSci原创

由此可见,EDS可能是心肌梗死后中度至重度睡眠呼吸障碍患者预后不良的独立预测因素。对EDS的评估有助于揭示危险分层,并明确这些人群的治疗反应。

白天过度嗜睡是睡眠呼吸障碍患者的常见症状,其与心血管疾病的发生密切相关,但其远期预后价值尚不完全清楚。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在明确EDS是否可以作为心肌梗死后独立的预后因素。

研究人员前瞻性地招募了112名心肌梗死后患者。在进行多导睡眠图前进行Epworth嗜睡量表检测,并且EDS被定义为得分≥11。排除了8例接受持续气道正压治疗的患者,104例患者随访48个月。主要的复合终点是主要的心脏不良事件。

研究人员发现EDS患者的主要不良心脏事件(48.4% vs. 27.4%,χ2=5.27,P=0.022)和心肌梗死(29% vs. 5.5%,χ2=13.51,P=0.0002)发生率较高,相比于那些没有EDS的受试者。在Cox比例风险模型中,EDS患者主要不良心脏事件风险增加2.15倍(95%可信区间为1.08-4.18;P=0.030),在调整年龄、糖尿病、抑郁症、左室射血分数、呼吸暂停低通气指数和夜间最低血氧饱和度后其预后意义仍然存在(风险比为2.13,95%可信区间为1.04-4.26,P=0.039)。此外,在中度至严重的睡眠呼吸紊乱患者中,在调整年龄和最低血氧饱和度(风险比为3.17,95%可信区间为1.22-7.76,P=0.019)后,EDS患者与没有EDS患者相比主要不良心脏事件风险更高。

由此可见,EDS可能是心肌梗死后中度至重度睡眠呼吸障碍患者预后不良的独立预测因素。对EDS的评估有助于揭示危险分层,并明确这些人群的治疗反应。

原始出处:


Jiang Xie,et al. Excessive Daytime Sleepiness Independently Predicts Increased Cardiovascular Risk After Myocardial Infarction.JAHA.2018. https://doi.org/10.1161/JAHA.117.007221

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    2018-09-15 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2018-01-22 zhaohui6731
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    2018-01-21 Ramsey

    学习了新知识.有意思

    0

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    2018-01-20 Y—xianghai

    学习了新知识

    0

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