Eur Heart J:肥厚型心肌病女性妊娠结局如何?

2017-05-12 xing.T MedSci原创

虽然大多数HCM妇女能过很好地耐受妊娠,但心血管并发症并不少见,并可以被妊娠前的状态所预测,而从易化了孕前咨询和有针对性的产前保健。

已有研究报道了与肥厚性心肌病(HCM)孕妇队列的参与者在生产时和6个月后母亲和胎儿的结局。虽然大多数HCM妇女耐受妊娠良好,但是产科和心血管并发症的风险增加。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员纳入了所有进入了前瞻性妊娠和心脏病全球登记中心(ROPAC)的HCM孕妇进行分析。该研究的主要终点为主要不良心血管事件(MACE),包括死亡、心力衰竭(HF)、血栓栓塞事件与心律失常。研究人员比较和分析了MACE患者与无MACE患者以及阻塞性HCM患者与非梗阻性HCM患者的基础和结局数据。

研究人员纳入了六十名HCM妊娠妇女(平均年龄为30.4±6岁)(41.7%为阻塞性)。在这个队列中没有产妇发生死亡。14例(23%)患者至少有一次MACE发生:9例(15%)HF患者和7例(12%)心律失常患者(6例心室颤动和1例房颤)。MACE发生最常见于孕晚期和产后期。总共有3名(5%)妇女经历了流产。有MACE的妇女有较高的因心脏原因紧急剖腹产率(21.4% vs. 0%,P=0.01)。梗阻性和非梗阻性HCM之间在妊娠结局上无显著性差异。NYHA心功能分级≥II和妊娠前HF体征与MACE相关。

虽然大多数HCM妇女能过很好地耐受妊娠,但心血管并发症并不少见,并可以被妊娠前的状态所预测,而从易化了孕前咨询和有针对性的产前保健。

原始出处:

S. Goland,et al. Pregnancy in women with hypertrophic cardiomyopathy: data from the European Society of Cardiology initiated Registry of Pregnancy and Cardiac disease (ROPAC). Eur Heart J. https://doi.org/10.1093/eurheartj/ehx189

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    2017-05-19 lou.minghong

    学习

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    2017-05-17 jyzxjiangqin

    肥厚型心肌病女性妊娠注意事项。

    0

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    2017-05-15 lixh1719

    HCM患者干嘛非要生孩子啊!母爱泛滥,对谁都不好

    0

  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197787, encodeId=565c19e78798, content=值得学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Sun May 14 06:47:46 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 虈亣靌

    学习了,谢谢分享。

    0

  5. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun May 14 11:32:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197930, encodeId=d15219e930c8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sun May 14 10:17:38 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197787, encodeId=565c19e78798, content=值得学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Sun May 14 06:47:46 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 zhaojie88
  8. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun May 14 11:32:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197930, encodeId=d15219e930c8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sun May 14 10:17:38 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197787, encodeId=565c19e78798, content=值得学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Sun May 14 06:47:46 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 slcumt
  9. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun May 14 11:32:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197930, encodeId=d15219e930c8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sun May 14 10:17:38 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197787, encodeId=565c19e78798, content=值得学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Sun May 14 06:47:46 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 Jackie Li

    学习

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197787, encodeId=565c19e78798, content=值得学习并分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Sun May 14 06:47:46 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 杨利洪

    值得学习并分享

    0

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