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NEJM：牛痘病毒感染-病例报道

2018-01-11 xing.T MedSci原创

牛痘病毒感染皮肤损伤
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牛痘病毒感染是一种罕见的人畜共患传染病。尽管其这个名字，但是人类可以从感染猫中传染牛痘病毒，且没有特异性的治疗方法。

患者为一名11岁的女孩，因其左侧脸颊上出现皮肤损伤3周而就诊。该患者居住在波兰郊区，在家中可以与自由散养的猫直接接触；没有咬伤或抓伤病史。她的父母报告最初有脓疱出现在女孩的左侧脸颊，它逐渐演变成一个带黑色焦痂的坏死性溃疡。焦痂直径为2厘米，伴有扩大的局部红斑（如图A所示）和颌下淋巴结肿大。该患者曾接受过经验性抗生素治疗，但没有改善。



病灶切开后无脓液，细菌培养阴性。医务人员从病变得到的拭子和血清样品标本采用经聚合酶链反应（PCR）方法进行病毒DNA和牛痘病毒特异性寡核苷酸检测。PCR反应检测到炭疽杆菌的DNA，血清学检测发现弗朗西丝菌和巴尔通氏体均为阴性。

牛痘病毒感染是一种罕见的人畜共患传染病。尽管其这个名字，但是人类可以从感染猫中传染牛痘病毒，且没有特异性的治疗方法。

这个患者愈合时间延长，对坏死的焦痂进行外科手术切除。3个月后，红斑残余区域围绕着一个1cm的瘢痕（如图B所示）。

原始出处：

Ewa Talarek,et al. Cowpox Virus Infection. N Engl J Med 2018; http://www.nejm.org/doi/full/10.1056/NEJMicm1702548

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    2020-11-04 120befd3m21暂无昵称

    学习啦~

    0

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    2018-05-04 liuyg0228

    #牛痘#

    0

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    2018-01-18 虈亣靌

    认真学习.天天向上

    0

  4. 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    2018-01-16 txqjm

    谢谢了.学习

    0

  5. 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    2018-01-11 龙胆草

    学习谢谢分享

    0

  6. 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    2018-01-11 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  7. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Thu Jan 11 06:53:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-01-11 Y—xianghai

    学习了新知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=896796, encodeId=4df4896e96a0, content=学习啦~, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=554e2203973, createdName=120befd3m21暂无昵称, createdTime=Wed Nov 04 09:32:05 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797995, encodeId=64591e97995b4, content=<a href='/topic/show?id=61446e766bc' target=_blank style='color:#2F92EE;'>#牛痘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67766, encryptionId=61446e766bc, topicName=牛痘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Fri May 04 11:45:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279705, encodeId=53092e97059d, content=认真学习.天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jan 18 13:15:15 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278886, encodeId=110a2e8886ee, content=谢谢了.学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Tue Jan 16 00:07:26 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277478, encodeId=259c2e747876, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Jan 11 09:19:25 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277469, encodeId=f8ee2e746951, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jan 11 09:01:51 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277458, encodeId=f9832e7458da, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 11 08:27:25 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277434, encodeId=83732e743455, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Thu Jan 11 06:53:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-01-11 榄枷檬

    谢谢分享

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=896796, encodeId=4df4896e96a0, content=学习啦~, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=554e2203973, createdName=120befd3m21暂无昵称, createdTime=Wed Nov 04 09:32:05 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797995, encodeId=64591e97995b4, content=<a href='/topic/show?id=61446e766bc' target=_blank style='color:#2F92EE;'>#牛痘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67766, encryptionId=61446e766bc, topicName=牛痘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Fri May 04 11:45:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), 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09:01:51 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277458, encodeId=f9832e7458da, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 11 08:27:25 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277434, encodeId=83732e743455, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Thu Jan 11 06:53:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-01-11 榄枷檬

    学习学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=896796, encodeId=4df4896e96a0, content=学习啦~, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=554e2203973, createdName=120befd3m21暂无昵称, createdTime=Wed Nov 04 09:32:05 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797995, encodeId=64591e97995b4, content=<a href='/topic/show?id=61446e766bc' target=_blank style='color:#2F92EE;'>#牛痘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67766, encryptionId=61446e766bc, topicName=牛痘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Fri May 04 11:45:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), 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09:01:51 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277458, encodeId=f9832e7458da, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 11 08:27:25 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277434, encodeId=83732e743455, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Thu Jan 11 06:53:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-01-11 小树

    这个家畜有时候确实得注意!

    0

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