创新点——国自然评审专家挑刺的**

2015-09-14 MedSci MedSci原创

从科学假设衍生出研究内容和目标,接下来提炼的内容便是课题的特色与创新,逻辑思路可谓一脉相承。首先明确:特色与创新来源于科学假设的原创性。我们还是以前面说到的科学假设:在某临床问题所对应的科学问题中,靶标分子X通过介导Y通路(分子)产生Z效应为例来说明。 先问自己,X分子具有Z效应是不是申请人的发现,如果是则此为创新点1; 再问自己,X分子介导Y通路发挥Z效应

从科学假设衍生出研究内容和目标,接下来提炼的内容便是课题的特色与创新,逻辑思路可谓一脉相承。首先明确:特色与创新来源于科学假设的原创性。我们还是以前面说到的科学假设:在某临床问题所对应的科学问题中,靶标分子X通过介导Y通路(分子)产生Z效应为例来说明。 先问自己,X分子具有Z效应是不是申请人的发现,如果是则此为创新点1; 再问自己,X分子介导Y通路发挥Z效应其中的机制是不是申请人原创,此为潜在创新点2; 然后,结合科学问题,问一问X→Y→Z调控通路是否在此问题中是一种新机理解释?如果是可作为创新点3; 最后,结合临床问题,探讨X是否具有临床转化价值?如果申请人首次提出其临床相关性可视为创新点4。 前面谈到研究内容不宜贪多,与此类似,青年基金一般有2-3项创新点足矣,而面上项目3项创新点则恰到好处,所以上面总结的创新采纳2-3条即可,无需全部罗列。 到了这个阶段,你会发现科学假设原创的重要性,如果申请人过多借鉴了文献中的思路,甚至照搬靶标分子和通路,就会发现无法总结出那么多条创新,临床、科学问题不新颖,靶标分子也有相关报道,这种情况下只能尝试从研究方法、模型、观察指标等细节入手寻找创新点

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1932001, encodeId=f63b1932001dc, content=<a href='/topic/show?id=3bd99151078' target=_blank style='color:#2F92EE;'>#评审专家#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91510, encryptionId=3bd99151078, topicName=评审专家)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Wed May 18 09:09:00 CST 2016, time=2016-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37543, encodeId=3e7e3e54343, content=对于我这样 的新手 不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5991653187, createdName=小样儿6275, createdTime=Tue Sep 29 10:36:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1285224, encodeId=f198128522478, content=<a href='/topic/show?id=77903209422' target=_blank style='color:#2F92EE;'>#创新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32094, encryptionId=77903209422, topicName=创新)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Wed Sep 16 13:09:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36948, encodeId=d9d13694855, content=更正pubmed, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:26:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36947, encodeId=8d603694e6a, content=创新点是非常头疼的,一般评委会把你标书中的关键字在punned 上面查一查,如果查到的文献量多就说你没有传信息,如果查到文献量太少,说你可行性不强,这确实很头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:25:00 CST 2015, time=2015-09-16, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1932001, encodeId=f63b1932001dc, content=<a href='/topic/show?id=3bd99151078' target=_blank style='color:#2F92EE;'>#评审专家#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91510, encryptionId=3bd99151078, topicName=评审专家)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Wed May 18 09:09:00 CST 2016, time=2016-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37543, encodeId=3e7e3e54343, content=对于我这样 的新手 不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5991653187, createdName=小样儿6275, createdTime=Tue Sep 29 10:36:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1285224, encodeId=f198128522478, content=<a href='/topic/show?id=77903209422' target=_blank style='color:#2F92EE;'>#创新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32094, encryptionId=77903209422, topicName=创新)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Wed Sep 16 13:09:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36948, encodeId=d9d13694855, content=更正pubmed, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:26:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36947, encodeId=8d603694e6a, content=创新点是非常头疼的,一般评委会把你标书中的关键字在punned 上面查一查,如果查到的文献量多就说你没有传信息,如果查到文献量太少,说你可行性不强,这确实很头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:25:00 CST 2015, time=2015-09-16, status=1, ipAttribution=)]
    2015-09-29 小样儿6275

    对于我这样 的新手 不错

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1932001, encodeId=f63b1932001dc, content=<a href='/topic/show?id=3bd99151078' target=_blank style='color:#2F92EE;'>#评审专家#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91510, encryptionId=3bd99151078, topicName=评审专家)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Wed May 18 09:09:00 CST 2016, time=2016-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37543, encodeId=3e7e3e54343, content=对于我这样 的新手 不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5991653187, createdName=小样儿6275, createdTime=Tue Sep 29 10:36:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1285224, encodeId=f198128522478, content=<a href='/topic/show?id=77903209422' target=_blank style='color:#2F92EE;'>#创新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32094, encryptionId=77903209422, topicName=创新)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Wed Sep 16 13:09:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36948, encodeId=d9d13694855, content=更正pubmed, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:26:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36947, encodeId=8d603694e6a, content=创新点是非常头疼的,一般评委会把你标书中的关键字在punned 上面查一查,如果查到的文献量多就说你没有传信息,如果查到文献量太少,说你可行性不强,这确实很头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:25:00 CST 2015, time=2015-09-16, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1932001, encodeId=f63b1932001dc, content=<a href='/topic/show?id=3bd99151078' target=_blank style='color:#2F92EE;'>#评审专家#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91510, encryptionId=3bd99151078, topicName=评审专家)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Wed May 18 09:09:00 CST 2016, time=2016-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37543, encodeId=3e7e3e54343, content=对于我这样 的新手 不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5991653187, createdName=小样儿6275, createdTime=Tue Sep 29 10:36:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1285224, encodeId=f198128522478, content=<a href='/topic/show?id=77903209422' target=_blank style='color:#2F92EE;'>#创新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32094, encryptionId=77903209422, topicName=创新)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Wed Sep 16 13:09:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36948, encodeId=d9d13694855, content=更正pubmed, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:26:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36947, encodeId=8d603694e6a, content=创新点是非常头疼的,一般评委会把你标书中的关键字在punned 上面查一查,如果查到的文献量多就说你没有传信息,如果查到文献量太少,说你可行性不强,这确实很头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:25:00 CST 2015, time=2015-09-16, status=1, ipAttribution=)]
    2015-09-16 medcardio

    更正pubmed

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1932001, encodeId=f63b1932001dc, content=<a href='/topic/show?id=3bd99151078' target=_blank style='color:#2F92EE;'>#评审专家#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91510, encryptionId=3bd99151078, topicName=评审专家)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Wed May 18 09:09:00 CST 2016, time=2016-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37543, encodeId=3e7e3e54343, content=对于我这样 的新手 不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5991653187, createdName=小样儿6275, createdTime=Tue Sep 29 10:36:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1285224, encodeId=f198128522478, content=<a href='/topic/show?id=77903209422' target=_blank style='color:#2F92EE;'>#创新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32094, encryptionId=77903209422, topicName=创新)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Wed Sep 16 13:09:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36948, encodeId=d9d13694855, content=更正pubmed, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:26:00 CST 2015, time=2015-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36947, encodeId=8d603694e6a, content=创新点是非常头疼的,一般评委会把你标书中的关键字在punned 上面查一查,如果查到的文献量多就说你没有传信息,如果查到文献量太少,说你可行性不强,这确实很头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:25:00 CST 2015, time=2015-09-16, status=1, ipAttribution=)]
    2015-09-16 medcardio

    创新点是非常头疼的,一般评委会把你标书中的关键字在punned 上面查一查,如果查到的文献量多就说你没有传信息,如果查到文献量太少,说你可行性不强,这确实很头疼

    0

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