Diabetic Med:二甲双胍治疗2型糖尿病与基因相互作用的优先顺序和富集

2017-11-30 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于二甲双胍治疗2型糖尿病与基因相互作用的优先顺序和富集的研究。

近日,国际杂志 《Diabetic Med》上在线发表一项关于二甲双胍治疗2型糖尿病与基因相互作用的优先顺序和富集的研究。 有大量文献表明多个位点参与调节二甲双胍的作用;然而大多数研究结果缺乏重复性,因此从假阳性中区分真正的阳性的结果是困难的。为了解决这个问题,研究人员进行了基于证据的多重数据整合来确定已发表证据的有效性。 研究人员使用自动文本挖掘方法(n=5963篇出版物)建立了基因 -二甲双胍相互作用的已发表数据的数据库,为每个报道的基因座设计了证据分数,并由此产生基因排序 (4)通过重复分析在来自糖尿病和审计研究的遗传学研究(Gays)研究(GWAS)数据集中确定了该基因集合在血糖反应中富集的程度( GoDARTS)。 从文献检索中,确定了与二甲双胍临床结果相关的七个基因。15个基因与二甲双胍药代动力学或药效学相关联,另外51个基因的表达谱被发现对二甲双胍响应。基因富集分析包括从上述三个派生的三个集合和两个以上的复合集合显示在四个基因没有显著的富集。然而,研究人员发现在二甲双胍血糖反应(p  = 0.03)中,在优先级最低的类别(其表达受二甲双胍影响的基因集合)中显着富

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    2017-12-02 ylz8405
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    2017-12-02 半夏微凉

    学习了谢谢分享

    0

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    2017-12-01 1209e435m98(暂无昵称)

    l学习了.谢谢分享!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1638230, encodeId=5fd2163823062, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Jan 09 09:38:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909224, encodeId=4c1619092246a, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Nov 12 15:38:00 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760375, encodeId=97641e603759a, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Feb 04 22:38:00 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970556, encodeId=43f319e05560f, content=<a href='/topic/show?id=fa5d5919df' target=_blank style='color:#2F92EE;'>#Diabetic#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5919, encryptionId=fa5d5919df, topicName=Diabetic)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Thu Aug 02 14:38:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471562, encodeId=418d14e15622e, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sat Dec 02 13:38:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608308, encodeId=56ef1608308b2, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Dec 02 13:38:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266149, encodeId=cbd1266149f4, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Dec 02 09:47:41 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265796, encodeId=c109265e96fa, content=l学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Fri Dec 01 00:06:26 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265788, encodeId=28b0265e8882, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Nov 30 23:09:58 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-11-30 清风拂面

    学习了.谢谢分享

    0