Gastric Cancer :血清ANOS1水平可作为胃癌的诊断生物标志物

2020-03-16 MedSci原创 MedSci原创

高性能血清生物标记物的开发可能会改善胃癌(GC)患者的预后。

背景:高性能血清生物标记物的开发可能会改善胃癌(GC)患者的预后。研究人员先前确定了候选血清标志物,anosmin 1(ANOS1),dihydropyrimidinase-like 3(DPYSL3)和黑素瘤相关抗原D2(MAGE-D2),并通过单中心回顾性分析评估了它们的临床意义。在这里,研究人员进行了一项前瞻性的多中心观察性研究,旨在验证这些潜在标志物的诊断性能。

方法:研究人员分析了GC患者和健康志愿者中三种潜在生物标志物手术前后的血清水平。使用ELISA对血清和GC组织水平进行定量。并进行了相关性分析。

结果:区分GC患者与健康对照的曲线下面积(AUC)值分别为ANOS1,DPYSL3和MAGED2为-0.7058、0.6188和0.5031。ANOS1分析的灵敏度和特异性分别为0.36和0.85。将IGC期患者与健康对照区分开的ANOS1的AUC值为0.7131。与健康对照组相比,I期GC患者的血清ANOS1水平显着升高(中位数分别为1179 ng / ml和461 ng / ml,P <0.0001),并在切除原发性GC病变后降低(P<0.0001)。血清ANOS1和DPYSL3水平的组合增加了AUC值,从而将GC患者与健康对照区分开来。血清ANOS1水平与癌胚抗原,碳水化合物抗原19–9或其他炎症标志物无显着相关性。

结论:血清ANOS1的水平可用作管理GC的优良的诊断工具。

原始出处:

Mitsuro Kanda. Et al. Serum levels of ANOS1 serve as a diagnostic biomarker of gastric cancer: a prospective multicenter observational study. Gastric Cancer .2020.

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    2020-12-21 skhzy
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    2020-04-03 许安
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    2020-03-16 xcdnxj

    编刊社

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