NEJM:Sotagliflozin联合胰岛素治疗I型糖尿病

2017-09-14 zhangfan MedSci原创

研究认为,对于I型糖尿病患者,Sotagliflozin联合胰岛素可有效控制患者血糖水平

对于大多数I型糖尿病患者,单纯的胰岛素治疗无法实现有效的血糖控制。近日研究人员评估了双重葡萄糖转运蛋白抑制剂Sotagliflozin联合胰岛素治疗I型糖尿病的疗效和安全性。

这项III期临床研究在133个中心进行,1402名I型糖尿病患者参与,患者随机接受胰岛素治疗联合Sotagliflozin (400 mg/d)或安慰剂,持续24周。主要终点是糖化血红蛋白低于7%患者且无严重低血糖或糖尿病酮症酸中毒患者比例,次要终点包括糖化血红蛋白变化、体重、血压以及日平均胰岛素剂量。

研究发现,Sotagliflozin组患者主要终点达标率显著高于安慰剂组 (200例[28.6%] vs. 107例[15.2%], P<0.001)。 Sotagliflozin组糖化血红蛋白变化、体重、血压以及日平均胰岛素剂量最小二乘均值变化均显著优于对照组。组间严重低血糖发生率相近(3% vs 2.4%),低于55mg/ 100mL的严重低血糖率Sotagliflozin组低于对照组,但糖尿病酮症酸中毒率Sotagliflozin组高于对照组(3.0% [21 例] vs 0.6% [4例])。

研究认为,对于I型糖尿病患者,Sotagliflozin联合胰岛素可有效控制患者血糖水平。

原始出处:

Satish K. Garg et al. Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes. N Engl J Med. September 14 2017.

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    2018-01-20 baoya
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    2017-09-15 184****9840

    学习了谢谢分享

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    Sotagliflozin联合胰岛素治疗I型糖尿病

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