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JACC：一种新的由红细胞介导的糖尿病致内皮功能不全机制

2018-08-13 MedSci MedSci原创

心血管糖尿病内皮红细胞
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心血管疾病是2型糖尿病（T2DM）的主要风险之一。既往研究报道了红细胞（RBCs）在心功能调节中的重要作用，T2DM患者的RBC功能有所改变，且精氨酸酶的活性有所增高。本研究的目的旨在证明T2DM患者的红细胞可以通过上调精氨酸酶水平引起内皮功能不全。本研究对T2DM患者和年龄匹配的对照的红细胞进行了分离，并与大鼠主动脉或非糖尿病患者的乳腺内动脉血管共培养。分析结果显示，T2DM患者的红细胞精氨酸酶

心血管疾病是2型糖尿病（T2DM）的主要风险之一。既往研究报道了红细胞（RBCs）在心功能调节中的重要作用，T2DM患者的RBC功能有所改变，且精氨酸酶的活性有所增高。本研究的目的旨在证明T2DM患者的红细胞可以通过上调精氨酸酶水平引起内皮功能不全。

本研究对T2DM患者和年龄匹配的对照的红细胞进行了分离，并与大鼠主动脉或非糖尿病患者的乳腺内动脉血管共培养。分析结果显示，T2DM患者的红细胞精氨酸酶和精氨酸酶I蛋白的表达水平升高，与T2DM患者红细胞共培养的大鼠主动脉或非糖尿病患者的乳腺内动脉血管内皮功能有所损坏，但平滑肌细胞功能不受影响。T2DM RBC引起的内皮功能不全可以通过抑制精氨酸酶和活性氧（ROS）来阻止。分子实验表明T2DM红细胞引起的精氨酸酶I蛋白的表达水平升高是通过ROS介导的。

本研究揭示了一种新的2型糖尿病引起内皮功能不全的机制，即是由红细胞精氨酸酶和活性氧介导的分子机制。

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    2019-04-22 hbwxf

    #JACC#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1854126, encodeId=18aa1854126b9, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Apr 22 17:25:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282012, encodeId=2ca1128201205, content=<a href='/topic/show?id=3dece71531e' target=_blank style='color:#2F92EE;'>#红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77153, encryptionId=3dece71531e, topicName=红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Wed Aug 15 10:25:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325932, encodeId=e344132593261, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Aug 15 10:25:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450044, encodeId=988f145004407, content=<a href='/topic/show?id=85eb304409c' target=_blank style='color:#2F92EE;'>#内皮功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30440, encryptionId=85eb304409c, topicName=内皮功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41d5536295, createdName=zhangxingru, createdTime=Wed Aug 15 10:25:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041776, encodeId=6a7e1041e7610, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Aug 13 22:25:00 CST 2018, time=2018-08-13, status=1, ipAttribution=)]
    2018-08-15 kord1982

    #红细胞#

    0

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    2018-08-15 12498568m50暂无昵称

    #ACC#

    0

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    2018-08-15 zhangxingru

    #内皮功能#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1854126, encodeId=18aa1854126b9, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Apr 22 17:25:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282012, encodeId=2ca1128201205, content=<a href='/topic/show?id=3dece71531e' target=_blank style='color:#2F92EE;'>#红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77153, encryptionId=3dece71531e, topicName=红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Wed Aug 15 10:25:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325932, encodeId=e344132593261, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Aug 15 10:25:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450044, encodeId=988f145004407, content=<a href='/topic/show?id=85eb304409c' target=_blank style='color:#2F92EE;'>#内皮功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30440, encryptionId=85eb304409c, topicName=内皮功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41d5536295, createdName=zhangxingru, createdTime=Wed Aug 15 10:25:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041776, encodeId=6a7e1041e7610, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Aug 13 22:25:00 CST 2018, time=2018-08-13, status=1, ipAttribution=)]
    2018-08-13 misszhang

    谢谢MedSci提供最新的资讯

    0

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