Diabetes Care:吃早餐可以触发适当的循环时钟基因表达,从而改善血糖控制

2017-12-03 佚名 Medicalxpress

不规律的饮食习惯,如不吃早餐,往往与肥胖,2型糖尿病,高血压和心血管疾病有关,但进餐时间对人体内部时钟的确切影响并不明显。

不规律的饮食习惯,如不吃早餐,往往与肥胖,2型糖尿病高血压和心血管疾病有关,但进餐时间对人体内部时钟的确切影响并不明显。

特拉维夫大学的一项新研究现在明确了早餐对调节餐后血糖和胰岛素反应的“时钟基因”的影响。

人体内部时钟的重要性以及用餐时间对身体的影响是今年诺贝尔医学奖的主题,该奖项旨在发现控制我们昼夜节律的分子机制。

Jakubowicz教授说:“我们的研究表明,吃早餐可以触发适当的循环时钟基因表达,从而改善血糖控制。”生物钟基因不仅调节葡萄糖代谢的昼夜变化,还能调节我们的体重、血压、内皮功能和动脉粥样硬化。

“适当的用餐时间,比如在9:30之前吃早餐——可能会改善身体的整个新陈代谢,促进体重减轻,延缓与2型糖尿病和其他与年龄有关的疾病相关的并发症。”

对于这项研究,18名健康志愿者和18名肥胖糖尿病志愿者参加了一个包含早餐和午餐的测试日,而在一个只有午餐的测试日中。在两天中,研究人员对参与者进行血液检查测量他们的餐后时钟基因的表达,血浆葡萄糖,胰岛素和完整胰高血糖素样肽-1(iGLP-1)和二肽基肽酶IV(DPP-IV)的血浆活性。

Jakubowicz教授说:“我们的研究表明,早餐的消费会触发适当的循环时钟基因表达,从而改善血糖控制。 “在健康人和糖尿病患者中,早餐消耗急剧改善了与更有效的体重减轻有关的特定时钟基因的表达,并且与午餐后改善的葡萄糖和胰岛素水平相关。

相比之下,在只有午餐(当参与者不吃早餐时)的测试日期中,与体重减轻有关的时钟基因被下调,导致血糖峰值和一天中其余时间的胰岛素反应差,这也表明,不吃早餐导致体重增加,即使没有暴饮暴食。

Jakubowicz教授说:“我们可以在短短四个小时内改变基因的表达,这一点非常令人印象深刻。研究人员目前正在进行一项长期研究,比较不同进餐时间安排对身体时钟基因表达,葡萄糖平衡和体重减轻随时间的影响。

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  5. 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href='/topic/show?id=23ce5951642' target=_blank style='color:#2F92EE;'>#早餐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59516, encryptionId=23ce5951642, topicName=早餐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=767c18890183, createdName=LSJ117, createdTime=Tue Dec 05 09:06:00 CST 2017, time=2017-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266528, encodeId=f1df2665289e, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sun Dec 03 21:23:07 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266510, encodeId=8e8e266510a7, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Dec 03 18:18:58 CST 2017, time=2017-12-03, status=1, ipAttribution=)]
    2017-12-06 飘飘爱

    很好

    0

  6. 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=1901871, encodeId=192a19018e12f, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Jun 14 12:06:00 CST 2018, time=2018-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760379, encodeId=d5791e603796d, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Dec 03 18:18:58 CST 2017, time=2017-12-03, status=1, ipAttribution=)]
    2017-12-05 LSJ117
  9. [GetPortalCommentsPageByObjectIdResponse(id=1901871, encodeId=192a19018e12f, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Jun 14 12:06:00 CST 2018, time=2018-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760379, encodeId=d5791e603796d, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, 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    2017-12-03 thlabcde

    好资料学习了!

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Dec 03 18:18:58 CST 2017, time=2017-12-03, status=1, ipAttribution=)]
    2017-12-03 wxl882001

    学习一下

    0

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