Bioimpacts:羧甲基纤维素/ MOF-5 /氧化石墨烯生物纳米复合物作为抗菌药物纳米载体剂

2019-05-13 不详 网络

近年来,越来越多的人开始关注开发药物输送系统设计的新方法。本研究旨在提高抗菌药物递送过程的效率,并实现和准确地控制释放。根据改良的Hummers法制备氧化石墨烯(GO),然后通过溶剂热技术用羧甲基纤维素(CMC)和Zn基金属-有机骨架(MOF-5)对GO进行改性。对所得生物纳米复合材料进行扫描电子显微镜(SEM),X射线衍射(XRD),EDX,傅里叶变换红外(FTIR)光谱和Zeta电位等各种检测

近年来,越来越多的人开始关注开发药物输送系统设计的新方法。本研究旨在提高抗菌药物递送过程的效率,并实现和准确地控制释放。

根据改良的Hummers法制备氧化石墨烯(GO),然后通过溶剂热技术用羧甲基纤维素(CMC)和Zn基金属-有机骨架(MOF-5)对GO进行改性。

对所得生物纳米复合材料进行扫描电子显微镜(SEM),X射线衍射(XRD),EDX,傅里叶变换红外(FTIR)光谱和Zeta电位等各种检测,证实GO的成功制备。采用常用的分析方法,确定了合成材料的结构,最后根据发酵液微量稀释法检测了其抗菌行为。

宗旨,该研究使用溶剂热法成功合成了羧甲基纤维素/ MOF-5 / GO生物纳米复合材料(CMC / MOF-5 / GO)。将四环素(TC)封装在GO和CMC / MOF-5 / GO中。药物释放试验表明,载有TC的CMC / MOF5 / GO具有有效的抗pH保护作用。通过控制肠道条件下的TC释放,药物剂量的长期稳定性得到增强。此外,抗菌活性测试表明,与TC负载的GO相比,TC负载的CMC / MOF-5 / GO具有抗大肠杆菌细菌负电荷的抗菌活性。

原始出处:

Karimzadeh Z, Javanbakht S, Namazi H. Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent. Bioimpacts. 2019;9(1):5-13. doi: 10.15171/bi.2019.02. Epub 2018 Jul 18.

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    2019-09-13 sunylz
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createdName=axin009, createdTime=Tue Jan 14 06:47:00 CST 2020, time=2020-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918676, encodeId=946419186e621, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Sep 13 06:47:00 CST 2019, time=2019-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075757, encodeId=db0520e5757da, content=<a href='/topic/show?id=2022e74603e' target=_blank style='color:#2F92EE;'>#纳米载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77460, encryptionId=2022e74603e, 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createdName=ms7899726347904398, createdTime=Wed May 15 10:47:00 CST 2019, time=2019-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373109, encodeId=72ea13e31099e, content=<a href='/topic/show?id=eb2555e176c' target=_blank style='color:#2F92EE;'>#抗菌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55717, encryptionId=eb2555e176c, topicName=抗菌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Wed May 15 10:47:00 CST 2019, time=2019-05-15, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1910634, encodeId=fe52191063418, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Mon Nov 18 08:47:00 CST 2019, time=2019-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798564, encodeId=21c21e9856489, content=<a href='/topic/show?id=b5d96943076' target=_blank style='color:#2F92EE;'>#生物纳米#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69430, encryptionId=b5d96943076, topicName=生物纳米)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Tue Jan 14 06:47:00 CST 2020, time=2020-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918676, encodeId=946419186e621, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Sep 13 06:47:00 CST 2019, time=2019-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075757, encodeId=db0520e5757da, content=<a href='/topic/show?id=2022e74603e' target=_blank style='color:#2F92EE;'>#纳米载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77460, encryptionId=2022e74603e, 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href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Fri Jun 14 16:47:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330819, encodeId=e4551330819a3, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Wed May 15 10:47:00 CST 2019, time=2019-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373109, encodeId=72ea13e31099e, content=<a href='/topic/show?id=eb2555e176c' target=_blank style='color:#2F92EE;'>#抗菌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55717, encryptionId=eb2555e176c, topicName=抗菌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Wed May 15 10:47:00 CST 2019, time=2019-05-15, status=1, ipAttribution=)]
    2019-10-18 mei539
  6. [GetPortalCommentsPageByObjectIdResponse(id=1910634, encodeId=fe52191063418, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Mon Nov 18 08:47:00 CST 2019, time=2019-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798564, encodeId=21c21e9856489, content=<a href='/topic/show?id=b5d96943076' target=_blank style='color:#2F92EE;'>#生物纳米#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69430, encryptionId=b5d96943076, topicName=生物纳米)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, 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href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Fri Jun 14 16:47:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330819, encodeId=e4551330819a3, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Wed May 15 10:47:00 CST 2019, time=2019-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373109, encodeId=72ea13e31099e, content=<a href='/topic/show?id=eb2555e176c' target=_blank style='color:#2F92EE;'>#抗菌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55717, encryptionId=eb2555e176c, topicName=抗菌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Wed May 15 10:47:00 CST 2019, time=2019-05-15, status=1, ipAttribution=)]
    2020-02-09 liao1627
  7. 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    2019-05-15 lhlxtx