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Sci Rep：利用磁性纳米粒子改善干细胞向小梁网的输送

2018-09-10 MedSci MedSci原创

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青光眼是导致失明的主要原因，并且通常与眼压升高有关。已知小梁网（TM）（主要调节眼内压的组织）在青光眼中具有降低的细胞性。因此，如果将干细胞适当地递送至TM，或可为青光眼患者的眼内压控制提供新的治疗选择。 本研究中个，研究人员使用磁性纳米颗粒（PBNCs）来标记间充质干细胞，并在注射到眼睛的前房后将其磁性转向到TM。PBNC标记的干细胞在暴露于磁场仅15分钟后显示出对TM与未标记细胞的递送增

青光眼是导致失明的主要原因，并且通常与眼压升高有关。已知小梁网（TM）（主要调节眼内压的组织）在青光眼中具有降低的细胞性。因此，如果将干细胞适当地递送至TM，或可为青光眼患者的眼内压控制提供新的治疗选择。

本研究中个，研究人员使用磁性纳米颗粒（PBNCs）来标记间充质干细胞，并在注射到眼睛的前房后将其磁性转向到TM。PBNC标记的干细胞在暴露于磁场仅15分钟后显示出对TM与未标记细胞的递送增加。此外，PBNC标记的间充质干细胞可以被递送到TM的整个圆周，这在没有磁性转向的情况下是不可能的。PBNCs不影响间充质干细胞活力或多能性。

综上所述，该研究结果表明，这种标记方法允许在临床有针对性地，相对高效地将干细胞递送至TM，是用于控制青光眼患者的高眼压的再生医学疗法的必要步骤。

原始出处：

E. J. Snider, K. P. Kubelick, et al., Improving Stem Cell Delivery to the Trabecular Meshwork Using Magnetic Nanoparticles. Sci Rep. 2018; 8: 12251.

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    2019-05-07 zjubiostat

    #纳米粒#

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    2018-11-18 sodoo

    #磁性纳米#

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    2018-09-12 ms920641618706883

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