Eur Heart J:显著三尖瓣返流随时间变化的进展和预后意义

2018-07-19 xiangting MedSci原创

识别显著TR进展风险升高的患者,加强超声心动图监测,并在早期进行有效治疗可以改善患者生存率。

这项研究旨在评估转诊中心大型登记中影响显著(中度和重度)三尖瓣返流(TR)进展的风险因素,及其对全因死亡率的影响。

在1000例病历记录有显著TR的患者中(平均年龄68±13岁;50.9%男性),当超声心动图显示为无或轻度TR时,对临床和超声心动图数据进行回顾性分析。排除先天性心脏病患者。根据两次超声心动图检查之间的间隔将研究人群分为四分位间距:组1:≤1.2年,n=251;组2:1.3-4.7年,n=248;组3:4.8-8.9年,n=251;组4:≥9.0年,n=250。

基线年龄[比值比(OR)1.02]、有起搏器和除颤器导联(OR 1.59)、轻度((vs.无)TR(OR 8.96)、三尖瓣环平面收缩期偏移减少(OR 0.86)、和三尖瓣环扩张(OR 1.06)与短时间内显著TR的进展独立相关。两次超声心动图检查之间进行的任何瓣膜手术(不伴三尖瓣手术)也与显著TR快速进展的风险较高相关(OR 1.58)。第二次超声心动图检查后中位2.9年的随访期间(有显著TR),42.1%的患者死亡。显著TR快速进展的患者生存率低于显著TR进展较慢的患者(log rank P=0.001)。显著TR的快速进展与全因死亡率独立相关(进展前一年的风险比:0.92,置信区间0.90-0.94;P<0.001)。

识别显著TR进展风险升高的患者,加强超声心动图监测,并在早期进行有效治疗可以改善患者生存率。

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    2018-07-21 zhaojie88
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    2018-07-21 slcumt
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    2018-07-20 张新亮1853311252142e2fm

    好好文献学习了

    0

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